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    標題: A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice
    作者: Sheu, Joen-Rong
    Chen, Zhih-Cherng
    Jayakumar, Thanasekaran
    Chou, Duen-Suey
    Yen, Ting-Lin
    Lee, Hsing-Ni
    Pan, Szu-Han
    Hsia, Chih-Hsuan
    Yang, Chih-Hao
    Hsieh, Cheng-Ying
    貢獻者: Taipei Med Univ, Grad Inst Med Sci, Coll Med
    Taipei Med Univ, Dept Pharmacol, Coll Med
    Chi Mei Med Ctr, Dept Cardiol
    Chia Nan Univ Pharm & Sci, Dept Pharm
    關鍵字: Cerebral-Ischemia
    Antithrombotic Therapy
    Photosensitizing Dye
    Murine Macrophages
    Reperfusion Injury
    Oxidative Stress
    Focal Ischemia
    日期: 2017-02-06
    上傳時間: 2018-11-30 15:56:49 (UTC+8)
    出版者: Nature Publishing Group
    摘要: Thrombosis and stroke are major causes of disability and death worldwide. However, the regular antithrombotic drugs may have unsatisfactory results and side effects. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers and some acute inflammation. Here, we explored the neuroprotective effects of platonin against middle cerebral artery occlusion (MCAO)-induced ischemic stroke in mice. Platonin(200 mu g/kg) substantially reduced cerebral infarct volume, brain edema, neuronal cell death and neurological deficit scores, and improved the MCAO-reduced locomotor activity and rotarod performance. Platonin(5-10 mu M) potently inhibited platelet aggregation and c-Jun NH2-terminal kinase (JNK) phosphorylation in collagen-activated platelets. The antiaggregation effect did not affect bleeding time but increased occlusion time in platonin(100 and 200 mu g/kg)-treated mice. Platonin(2-10 mu M) was potent in diminishing collagen-and Fenton reaction-induced (OH)-O-center dot formation. Platonin(5-10 mu M) also suppressed the expression of nitric oxide, inducible nitric oxide synthase, cyclooxygenase-2, interleukin-1 beta, and JNK phosphorylation in lipopolysaccharide-stimulated macrophages. MCAO-induced expression of 3-nitrotyrosine and Iba1 was apparently attenuated in platonin(200 mu g/kg)-treated mice. In conclusion, platonin exhibited remarkable neuroprotective properties against MCAO-induced ischemia in a mouse model through its antiaggregation, antiinflammatory and antiradical properties. The observed therapeutic efficacy of platonin may consider being a novel medcine against ischemic stroke.
    關聯: Scientific Reports, v.7, pp.42277
    顯示於類別:[藥學系(所)] 期刊論文


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