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    標題: VEGF expression correlates with neuronal differentiation and predicts a favorable prognosis in patients with neuroblastoma
    作者: Weng, Wen-Chin
    Lin, Kuan-Hung
    Wu, Pei-Yi
    Ho, Ya-Hsuan
    Liu, Yen-Lin
    Wang, Bo-Jeng
    Chen, Chien-Chin
    Lin, Yueh-Chien
    Liao, Yung-Feng
    Lee, Wang-Tso
    Hsu, Wen-Ming
    Lee, Hsinyu
    貢獻者: Natl Taiwan Univ Hosp, Dept Pediat
    Natl Taiwan Univ, Coll Med
    Natl Taiwan Univ, Dept Life Sci
    Acad Sinica, Inst Cellular & Organism Biol
    Taipei Med Univ Hosp, Dept Pediat
    Chia Yi Christian Hosp
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Natl Taiwan Univ Hosp, Dept Surg
    Natl Taiwan Univ, Dept Elect Engn
    Natl Taiwan Univ, Angiogenesis Res Ctr
    Natl Taiwan Univ, Res Ctr Dev Biol & Regenerat Med
    Natl Taiwan Univ, Ctr Biotechnol
    關鍵字: Anti-Angiogenesis
    Gene-Expression
    Messenger-Rna
    Up-Regulation
    Calreticulin
    Tumor
    Cells
    Growth
    Amplification
    Receptors
    日期: 2017-09-11
    上傳時間: 2018-11-30 15:56:46 (UTC+8)
    出版者: Nature Publishing Group
    摘要: Neuroblastoma (NB) is a childhood cancer with a low survival rate and great metastatic potential. Vascular endothelial growth factor (VEGF), an angiogenesis factor, has been found to be involved in CRT-related neuronal differentiation of NB cells. In this study, we further confirmed the role VEGF in NB through mouse xenograft model and clinical analysis from NB patients. In xenograft experiments, CRT overexpression effectively inhibited the tumor growth. In addition, the mRNA and protein levels of VEGF and differentiation marker GAP-43 were upregulated by induced CRT expression. However, no significant correlation between the expression level of VEGF and microvessel density was observed in human NB tumors, suggesting a novel mechanism of VEGF participating in NB tumorigenesis through an angiogenesis-independent pathway. In NB patients' samples, mRNA expression levels of CRT and VEGF were positively correlated. Furthermore, positive VEGF expression by immunostaining of NB tumors was found to correlate well with histological grade of differentiation and predicted a favorable prognosis. In conclusion, our findings suggest that VEGF is a favorable prognostic factor of NB and might affect NB tumor behavior through CRT-driven neuronal differentiation rather than angiogenesis that might shed light on a novel therapeutic strategy to improve the outcome of NB.
    關聯: Scientific Reports, v.7, pp.11212
    顯示於類別:[化妝品應用與管理系(所)] 期刊論文

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