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    標題: Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling
    作者: Hsu, Hui-Ping
    Lai, Ming-Derg
    Lee, Jenq-Chang
    Yen, Meng-Chi
    Weng, Tzu-Yang
    Chen, Wei-Ching
    Fang, Jung-Hua
    Chen, Yi-Ling
    貢獻者: Natl Cheng Kung Univ, Coll Med,Natl Cheng Kung Univ Hosp, Dept Surg
    Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol
    Natl Cheng Kung Univ, Inst Basic Med Sci, Coll Med
    Kaohsiung Med Univ,Kaohsiung Med Univ Hosp, Dept Emergency Med
    Natl Cheng Kung Univ, Coll Med, Lab Anim Ctr
    Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
    Chia Nan Univ Pharm & Sci, Senior Citizen Dev Ctr
    關鍵字: Colorectal-Cancer
    Gene-Expression
    Gastric-Cancer
    Cell-Adhesion
    Oligonucleotide Arrays
    Poor-Prognosis
    Animal-Model
    Serum Levels
    Carcinoma
    Tumor
    日期: 2017-07-19
    上傳時間: 2018-11-30 15:56:44 (UTC+8)
    出版者: Nature Publishing Group
    摘要: Downregulation of Mucin 2 (MUC2) expression is associated with early carcinogenesis events in colon cancer. MUC2 plays a role in the progression of colon cancer, and reduced MUC2 protein expression correlates with increased interleukin-6 (IL-6) expression. However, the interaction between MUC2 and IL-6 in colorectal cancer metastasis remains unclear. We systematically analyzed MUC2 and IL-6 expression and determined the survival of cancer patients with high or low MUC2 and IL-6 expression using the Oncomine and PrognoScan databases, respectively. This analysis identified downregulation of MUC2 and overexpression of IL-6 in colon cancer but not in normal colon tissue, and this expression pattern was correlated with poor survival of colon cancer patients. We examined the effects of MUC2 on colon cancer metastasis and used vector-mediated application of short hairpin RNA (shRNA) to suppress MUC2 expression. MUC2 suppressed the migration of colon cancer cells in vitro and dramatically diminished liver metastases in vivo. Treatment with IL-6 increased signal transducer and activator of transcription 3 (STAT3) phosphorylation, promoted checkpoint kinase 2 (Chk2) activation, attenuated cAMP response element-binding protein (CREB) phosphorylation, and suppressed E-cadherin protein expression in MUC2-silenced HT-29 cancer cells. Most importantly, MUC2 is a potential prognostic indicator for colon cancer.
    關聯: Scientific Reports, v.7, pp.5823
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