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    標題: Recommendation for incorporation of a different lymph node scoring system in future AJCC N category for oral cancer
    作者: Lee, Ching-Chih
    Su, Yu-Chieh
    Hung, Shih-Kai
    Chen, Po-Chun
    Huang, Chung-I.
    Huang, Wei-Lun
    Lin, Yu-Wei
    Yang, Ching-Chieh
    貢獻者: Kaohsiung Vet Gen Hosp, Dept Otolaryngol Head & Neck Surg
    Natl Def Med Ctr, Sch Med
    Triserv Gen Hosp, Dept Otolaryngol Head & Neck Surg
    Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm
    Natl Yang Ming Univ, Sch Med
    E Da Hosp, Dept Hematol & Oncol
    I Shou Univ, Sch Med, Coll Med
    Buddhist DalinTzu Chi Hosp, Dept Radiat Oncol
    Tzu Chi Univ, Sch Med
    Pingtung Christian Hosp, Dept Radiat Oncol
    E Da Canc Hosp, Dept Radiat Oncol
    Kaohsiung Vet Gen Hosp, Dept Radiat Oncol
    Chi Mei Med Ctr, Dept Radiat Oncol
    Natl Sun Yat Sen Univ, Inst Biomed Sci
    Chia Nan Univ Pharm & Sci, Dept Pharm
    關鍵字: Squamous-Cell Carcinoma
    Log Odds
    日期: 2017-10-26
    上傳時間: 2018-11-30 15:56:39 (UTC+8)
    出版者: Nature Publishing Group
    摘要: To compare the prognostic value of 3 different lymph node scoring systems "log odds of positive nodes (LODDS), lymph node ratio (rN), and lymph node yield "in an effort to improve the staging of oral cancer. We identified 3958 oral cancer patients from Surveillance, Epidemiology, and End Results database from 2007 to 2013. In univariate analysis, LODDS, pN, rN, and lymph node yield were prognostic factors for 5-year disease-specific survival (DSS) and overall survival (OS). Multivariate analysis indicated that patients with LODDS 4 had worst 5-year DSS and OS. Stage migration occurred in pN1 and pN2 patients with LODDS 4. In pN1 patients, those with LODDS 4 had the worst 5-year DSS (41.2%) and OS (31.6%) than patients with pN1 and LODDS 2-3. In pN2 patients, those with LODDS4 had the worst 5-year DSS (34.5%) and OS (27.4%) than patients with pN2 and LODDS 2-3. The proposed staging system, which incorporates LODDS with AJCC pN, had better discriminability and prediction accuracy for predicting survival. We also noted that patients with LODDS 4 given adjuvant radiotherapy had better 5-year DSS and OS. The LODDS should be considered as a future candidate measurement for N category in oral cancer.
    關聯: Scientific Reports, v.7, pp.14117
    顯示於類別:[藥學系(所)] 期刊論文


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