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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31782


    標題: The prognostic value of N-terminal proB-type natriuretic peptide in patients with acute respiratory distress syndrome
    作者: Lai, Chih-Cheng
    Sung, Mei-I.
    Ho, Chung-Han
    Liu, Hsiao-Hua
    Chen, Chin-Ming
    Chiang, Shyh-Ren
    Chao, Chien-Ming
    Liu, Wei-Lun
    Hsing, Shu-Chen
    Cheng, Kuo-Chen
    貢獻者: Chi Mei Med Ctr, Dept Intens Care Med
    Chi Mei Med Ctr, Dept Internal Med
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci
    Chi Mei Med Ctr, Dept Intens Care Med
    Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm Engn
    關鍵字: Berlin Definition
    Heart-Failure
    Lung Injury
    Brain
    Outcomes
    Severity
    Utility
    Ards
    日期: 2017-03-21
    上傳時間: 2018-11-30 15:56:32 (UTC+8)
    出版者: Nature Publishing Group
    摘要: We investigated whether N-terminal proB-type natriuretic peptide (NT-proBNP) predicts the prognosis of patients with acute respiratory distress syndrome (ARDS). Between December 1, 2012, and May 31, 2015, this observational study recruited patients admitted to our tertiary medical center who met the Berlin criteria for ARDS and who had their NT-proBNP measured. The main outcome was 28-day mortality. We enrolled 61 patients who met the Berlin criteria for ARDS: 7 were classified as mild, 29 as moderate, and 25 as severe. The median APACHE II scores were 23 (interquartile range [IQR], 18-28), and SOFA scores were 11 (IQR, 8-13). The median lung injury score was 3.0 (IQR, 2.50-3.25), and the median level of NT-proBNP was 2011 pg/ml (IQR, 579-7216). Thirty-four patients died during this study, and the 28-day mortality rate was 55.7%. Patients who die were older and had significantly (all p < 0.05) higher APACHE II scores and NT-proBNP levels than did patients who survived. Multivariate analysis identified age (HR: 1.546, 95% CI: 1.174-2.035, p = 0.0019) and NT-proBNP (HR: 1.009, 95% CI: 1.004-1.013, p = 0.0001) as significant risk factors of death. NT-proBNP was associated with poor outcomes for patients with ARDS, and its level predicted mortality.
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