English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 16556/18969 (87%)
造訪人次 : 5341879      線上人數 : 107
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/31780

    標題: Klebsiella pneumoniae Isolates from Meningitis: Epidemiology, Virulence and Antibiotic Resistance
    作者: Ku, Yee-Huang
    Chuang, Yin-Ching
    Chen, Chi-Chung
    Lee, Mei-Feng
    Yang, Yan-Chang
    Tang, Hung-Jen
    Yu, Wen-Liang
    貢獻者: Chi Mei Med Ctr Liouying, Dept Internal Med, Div Infect Dis
    Chi Mei Med Ctr, Dept Med Res
    Chi Mei Hosp, Dept Internal Med, Div Infect Dis
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chi Mei Med Ctr, Dept Intens Care Med
    Taipei Med Univ, Coll Med, Sch Med, Dept Med
    關鍵字: Acquired Bacterial-Meningitis
    Multilocus Sequence Types
    Pyogenic Liver-Abscess
    Southern Taiwan
    Clinical Characteristics
    Clonal Dissemination
    日期: 2017-07-26
    上傳時間: 2018-11-30 15:56:28 (UTC+8)
    出版者: Nature Publishing Group
    摘要: Klebsiella pneumoniae (KP) resistance to broad-spectrum cephalosporin (BSC) in meningitis is important because of limited therapeutic options. To investigate the antibiotic resistance, virulence and epidemiology of KP in meningitis, we conducted a retrospective study for 33 non-metastatic isolates, including primary meningitis (n = 20) and post-craniotomy meningitis (n = 13) collected from 1999 to 2013. BSC resistance was found in 9 (27.3%) isolates, all from post-craniotomy meningitis, harboring bla(SHV-5) (n = 6), bla(CMY-2) (n = 2), bla(DHA-1) (n = 2), and bla(TEM-1B) (n = 1). Positive virulence factors were hypermucoviscosity (n = 22), larger bacterial size (n = 24), virulent capsule serotypes (n = 24, K2, 11; K1, 5; K57, 3; K5, 2; K20, 2 and K54, 1), rmpA (n = 23), rmpA2 (n = 20), aerobactin gene (n = 22) and high-grade serum resistance (n = 23, 69.7%). Higher mouse lethality (LD50 < 10(6)) was found in 16 isolates (48.5%). Post-craniotomy isolates were significantly less virulent than primary meningitis isolates, except for similar serum resistance capability. The pulsotype and sequence typing (ST) results were diverse. A minor cluster with pulsotype C and ST23 (n = 5) was identified in primary meningitis isolates. In conclusion, virulence factors and BSC resistance corresponded to about 70% and 30% of KP meningitis isolates respectively. BSC remains appropriate for treating primary meningitis, whereas meropenem is indicated for post-craniotomy meningitis empirically.
    關聯: Scientific Reports, v.7, pp.6634
    顯示於類別:[保健營養系(所) ] 期刊論文


    檔案 描述 大小格式瀏覽次數
    10.1038-s41598-017-06878-6.pdf1721KbAdobe PDF0檢視/開啟

    在CNU IR中所有的資料項目都受到原著作權保護.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋