English  |  正體中文  |  简体中文  |  Items with full text/Total items : 16713/19009 (88%)
Visitors : 5605100      Online Users : 91
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31780


    標題: Klebsiella pneumoniae Isolates from Meningitis: Epidemiology, Virulence and Antibiotic Resistance
    作者: Ku, Yee-Huang
    Chuang, Yin-Ching
    Chen, Chi-Chung
    Lee, Mei-Feng
    Yang, Yan-Chang
    Tang, Hung-Jen
    Yu, Wen-Liang
    貢獻者: Chi Mei Med Ctr Liouying, Dept Internal Med, Div Infect Dis
    Chi Mei Med Ctr, Dept Med Res
    Chi Mei Hosp, Dept Internal Med, Div Infect Dis
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chi Mei Med Ctr, Dept Intens Care Med
    Taipei Med Univ, Coll Med, Sch Med, Dept Med
    關鍵字: Acquired Bacterial-Meningitis
    Multilocus Sequence Types
    Pyogenic Liver-Abscess
    Prognostic-Factors
    Southern Taiwan
    Clinical Characteristics
    Clonal Dissemination
    Hong-Kong
    Prevalence
    Serotypes
    日期: 2017-07-26
    上傳時間: 2018-11-30 15:56:28 (UTC+8)
    出版者: Nature Publishing Group
    摘要: Klebsiella pneumoniae (KP) resistance to broad-spectrum cephalosporin (BSC) in meningitis is important because of limited therapeutic options. To investigate the antibiotic resistance, virulence and epidemiology of KP in meningitis, we conducted a retrospective study for 33 non-metastatic isolates, including primary meningitis (n = 20) and post-craniotomy meningitis (n = 13) collected from 1999 to 2013. BSC resistance was found in 9 (27.3%) isolates, all from post-craniotomy meningitis, harboring bla(SHV-5) (n = 6), bla(CMY-2) (n = 2), bla(DHA-1) (n = 2), and bla(TEM-1B) (n = 1). Positive virulence factors were hypermucoviscosity (n = 22), larger bacterial size (n = 24), virulent capsule serotypes (n = 24, K2, 11; K1, 5; K57, 3; K5, 2; K20, 2 and K54, 1), rmpA (n = 23), rmpA2 (n = 20), aerobactin gene (n = 22) and high-grade serum resistance (n = 23, 69.7%). Higher mouse lethality (LD50 < 10(6)) was found in 16 isolates (48.5%). Post-craniotomy isolates were significantly less virulent than primary meningitis isolates, except for similar serum resistance capability. The pulsotype and sequence typing (ST) results were diverse. A minor cluster with pulsotype C and ST23 (n = 5) was identified in primary meningitis isolates. In conclusion, virulence factors and BSC resistance corresponded to about 70% and 30% of KP meningitis isolates respectively. BSC remains appropriate for treating primary meningitis, whereas meropenem is indicated for post-craniotomy meningitis empirically.
    關聯: Scientific Reports, v.7, pp.6634
    Appears in Collections:[保健營養系(所) ] 期刊論文

    Files in This Item:

    File Description SizeFormat
    10.1038-s41598-017-06878-6.pdf1721KbAdobe PDF0View/Open
    index.html0KbHTML35View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback