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    標題: Long-term risk of dementia after acute respiratory failure requiring intensive care unit admission
    作者: Lai, Chih-Cheng
    Ho, Chung-Han
    Chen, Chin-Ming
    Chiang, Shyh-Ren
    Chao, Chien-Ming
    Liu, Wei-Lun
    Lin, Yu-Chieh
    Wang, Jhi-Joung
    Cheng, Kuo-Chen
    貢獻者: Chi Mei Med Ctr, Dept Intens Care Med
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Chi Mei Med Ctr, Dept Intens Care Med
    Chia Nan Univ Pharm Sci
    Mei Med Ctr, Dept Internal Med
    Chi Mei Med Ctr, Dept Family Med
    Chi Mei Med Ctr, Dept Anesthesiol
    Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm Engn
    關鍵字: Elderly Medicare Beneficiaries
    Critical Illness
    Cognitive Dysfunction
    Distress-Syndrome
    Disease
    Epidemiology
    Impairment
    Survivors
    Outcomes
    Injury
    日期: 2017-07-24
    上傳時間: 2018-11-30 15:55:50 (UTC+8)
    出版者: Public Library Science
    摘要: This retrospective, population-based cohort study aims to investigate the long-term risk of newly diagnosed dementia in patients discharged for acute respiratory failure that required mechanical ventilation (MV) and intensive care unit (ICU) admission. From the Taiwan National Health Insurance Research Database, first-time ICU patients using MV between June 1, 1998, and December 31, 2012, were enrolled, and they were followed-up until the earliest onset of one of our two endpoints: a new diagnosis of dementia (primary endpoint), or the end of the study. A total of 18,033 patients were enrolled and thirteen hundred eighty-seven patients had been newly diagnosed with dementia (mean onset: 3.2 years post-discharge). Patients >= 85 years old had the highest risk (multivariate analysis). Males had a lower risk than did females in both models (HR: 0.81, 95% CI: 0.72-0.9 in model 1; HR: 0.80, 95% CI: 0.72-0.89 in model 2). ICU stays > 5 days, hospital stays > 14 days, and more ICU readmissions were associated with a higher risk of developing dementia. In conclusion, the long-term risks of a subsequent diagnosis of dementia for acute respiratory failure with MV patients who survive to discharge increase with age and are higher in women than in men. Additionally, the longer the ICU or hospital stay is, and the more ICU readmissions a patient has, are both significantly associated with developing dementia.
    關聯: Plos One, v.12, n.7, e0180914
    顯示於類別:[藥學系(所)] 期刊論文

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