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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31759


    標題: Bidirectional association between ESRD dialysis and diabetes: National cohort study
    作者: Chu, Yeh-Wen
    Wu, Wen-Shiann
    Hsu, Chen-Fang
    Wang, Jhi-Joung
    Weng, Shih-Feng
    Chien, Chih-Chiang
    貢獻者: Chi Mei Med Ctr, Dept Nephrol
    Chi Mei Med Ctr, Dept Cardiol
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Chi Mei Med Ctr, Dept Pediat
    Chi Mei Med Ctr, Dept Med Res
    Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat
    關鍵字: Stage Renal-Disease
    Glucose-Intolerance
    Insulin-Resistance
    Mortality
    Taiwan
    Hemodialysis
    Mellitus
    Impact
    日期: 2017-03-15
    上傳時間: 2018-11-30 15:55:38 (UTC+8)
    出版者: Public Library Science
    摘要: Background Diabetes is associated with development of end-stage renal disease (ESRD) dialysis, but it is not clear whether ESRD dialysis is a risk factor for new-onset diabetes (NODM). Methods Using the Taiwan National Health Insurance Research Database, we designed two cohort studies to determine the association between dialysis and diabetes. Analysis 1 estimated the hazard ratios (HR) of ESRD dialysis in 20,585 patients with type 2 diabetes (T2DM) and 82,340 gender- and age-matched controls without diabetes. Analysis 2 estimated the HRs of NODM in 18,489 ESRD patients undergoing dialysis and 73,956 gender- and age matched controls without ESRD dialysis. The follow-up period was from 2000 to date of endpoint, the date of death, or December 31, 2008. Cox proportional models were used to estimate the relative hazards. Results In analysis 1, the incidence of ESRD dialysis was higher in the T2DM cohort than in the non diabetes cohort (6.78 vs. 0.61 per 1,000 person-years; HR: 7.97; 95%X1: 7.05-8.00). In analysis 2, the incidence of NODM was higher in the ESRD dialysis cohort than in the without-ESRD dialysis cohort (22.84 vs. 13.99 per 1,000 person-years; HR: 1.40; 95% CI: 1.34-1.47). Conclusions ESRD dialysis and diabetes were bidirectionally associated. The relationship between T2DM and incident ESRD dialysis was much stronger than between ESRD dialysis and NODM. Further studies are needed to determine the mechanism of ESRD dialysis-related NODM.
    關聯: Plos One, v.12, n.3, e0173785
    Appears in Collections:[藥學系(所)] 期刊論文

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