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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31755


    標題: Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1-like Diabetic Rats
    作者: Lo, Shih-Hsiang
    Hsu, Chao-Tien
    Niu, Ho-Shan
    Niu, Chiang-Shan
    Cheng, Juei-Tang
    Chen, Zhih-Cherng
    貢獻者: Taipei City Hosp, Zhongxing Branch, Dept Internal Med
    Tzu Chi Univ Sci & Technol, Dept Nursing
    I Shou Univ, E DA Hosp, Dept Pathol
    Chi Mei Med Ctr, Dept Cardiol
    Chi Mei Med Ctr, Dept Med Res
    Chang Jung Christian Univ, Inst Med Sci
    Chia Nan Univ Pharm & Sci, Dept Pharm
    關鍵字: cryptotanshinone
    STAT3
    type 1 diabetes
    cardiomyopathy
    cardiac fibrosis
    STZ rats
    日期: 2017-04
    上傳時間: 2018-11-30 15:55:28 (UTC+8)
    出版者: Wiley
    摘要: Cryptotanshinone is an active principal ingredient isolated from Salvia miltiorrhiza (Danshen), a medicinal plant used in China to treat cardiac disorders. The objective of this study was to investigate the effect of cryptotanshinone on myocardial fibrosis in diabetic rats. In streptozotocin-induced type 1 diabetic model hyperglycemic rats (STZ-treated rats), fasting blood glucose levels and heart weight/body weight ratio were markedly increased but both were not modified by cryptotanshinone. Additionally, cardiac performance in catheterized STZ-treated rats was improved. The histological results from Masson staining showed that cryptotanshinone attenuated cardiac fibrosis in STZ-treated rats. Moreover, both the mRNA and protein levels of the signal transducer and activator of transcription 3 (STAT3), matrix metalloproteinase-9, and connective tissue growth factor were reduced by cryptotanshinone in high glucose-cultured cardiomyocytes, similar to the reductions observed in the hearts of STZ-treated rats. In conclusion, while STAT3 regulates matrix metalloproteinase-9 and connective tissue growth factor expression in diabetic rats with cardiac fibrosis, cryptotanshinone inhibited fibrosis to improve cardiac function by suppressing the STAT3 pathway. Cryptotanshinone is suitable as an alternative remedy for therapy of cardiac fibrosis. Copyright (c) 2017 John Wiley & Sons, Ltd.
    Appears in Collections:[藥學系(所)] 期刊論文

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