Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31749
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    Title: Increased risk of brain cancer incidence in stroke patients: a clinical case series, population-based and longitudinal follow-up study
    Authors: Chen, Chih-Wei
    Cheng, Tain-Junn
    Ho, Chung-Han
    Wang, Jhi-Joung
    Weng, Shih-Feng
    Hou, Ya-Chin
    Cheng, Hung-Chi
    Chio, Chung-Ching
    Shan, Yan-Shen
    Chang, Wen-Tsan
    Contributors: Natl Cheng Kung Univ, Coll Med, Inst Clin Med
    Chi Mei Fdn Med Ctr, Dept Surg, Div Neurosurg
    Chia Nan Univ Pharm & Sci, Dept Occupat Safety & Health, Inst Ind Safety & Disaster Prevent, Coll Sustainable Environm
    Chi Mei Fdn Med Ctr, Dept Neurol & Occupat Med
    Chi Mei Fdn Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Chi Mei Fdn Med Ctr, Dept Anesthesiol
    Kaohsiung Med Univ, Dept Hlth Care Adm & Med Informat
    Natl Cheng Kung Univ, Dept Biochem & Mol Biol, Coll Med
    Natl Cheng Kung Univ, Div Gen Surg, Dept Surg, Coll Med
    Keywords: stroke
    ischemic stroke
    brain cancer
    glioblastoma mutiforme (GBM)
    nationwide population-based cohort
    Date: 2017-12-12
    Issue Date: 2018-11-30 15:55:16 (UTC+8)
    Publisher: Impact Journals Llc
    Abstract: Stroke and brain cancer are two distinct diseases. However, the relationship between both diseases has rarely been examined. This study investigated the longitudinal risk for developing brain cancer in stroke patients. To study this, we first reviewed the malignant gliomas previously with or without stroke using brain magnetic resonance imaging (MRI) images and the past histories. Two ischemic stroke patients before the malignant glioma were identified and belonged to the glioblastoma mutiforme (GBM). Particularly, both GBM specimens displayed strong hypoxia-inducible factor 1 alpha (HIF-1 alpha) expression in immunohistochemical (IHC) staining. To elucidate the significance of this relationship, we then used a nationwide population-based cohort in Taiwan to investigate the risk for the incidence of brain cancer in patients previously with or without stroke. The incidence of all tumors in the stroke group was lower than that in the control group with an adjusted hazard ratio (HR) of 0.79 (95% confidence interval [CI]: 0.74-0.84) in both gender and age older than 60 years. But the stroke patients had higher risk of developing only brain cancer with an adjusted HR of 3.09 (95% CI: 1.80-5.30), and otherwise had lower risk of developing head and neck, digestive, respiratory, bone and skin, as well as other tumors, all with p< 0.05. After stratification by gender and age, the female and aged 40-60 year old stroke patients had higher risk of developing brain cancer with an adjusted HR of 7.41 (95% CI: 3.30-16.64) and 16.34 (95% CI: 4.45-62.13), respectively, both with p<0.05. Patients with stroke, in particular female and age 40-60 years old, have an increased risk for developing brain cancer.
    Relation: Oncotarget, v.8, n.65, pp.108989-108999
    Appears in Collections:[Dept. of Hospital and Health (including master's program)] Periodical Articles
    [Dept. of Occupational Safety] Periodical Articles

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