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    標題: End stage renal disease is associated with development of dementia
    作者: Hung, Peir-Haur
    Yeh, Chih-Ching
    Hsiao, Chih-Yen
    Sung, Pi-Shan
    Muo, Chih-Hsin
    Sung, Fung-Chang
    Hung, Kuan-Yu
    Tsai, Kuen-Jer
    貢獻者: Ditmanson Med FdnChiayi Christian Hosp, Dept Internal Med
    Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
    Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth
    China Med Univ, Dept Publ Hlth
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Natl Cheng Kung Univ, Coll Med, Inst Clin Med
    Natl Cheng Kung Univ Hosp, Dept Neurol
    China Med Univ Hosp, Management Off Hlth Data
    China Med Univ, Coll Med, Sch Med, Grad Inst Clin Med Sci
    Natl Taiwan Univ Hosp, Hsinchu Branch, Dept Internal Med
    Natl Cheng Kung Univ, Coll Med,Natl Cheng Kung Univ Hosp, Ctr Clin Med
    關鍵字: Alzheimer's disease
    end stage renal disease
    hemodialysis
    peritoneal dialysis
    dementia
    Gerotarget
    日期: 2017-12-08
    上傳時間: 2018-11-30 15:55:13 (UTC+8)
    出版者: Impact Journals Llc
    摘要: There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia.
    關聯: Oncotarget, v.8, n.64, pp.107348-107355
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