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    標題: Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer
    作者: Shan, Yan-Shen
    Hsu, Hui-Ping
    Lai, Ming-Derg
    Hung, Yu-Hsuan
    Wang, Chih-Yang
    Yen, Meng-Chi
    Chen, Yi-Ling
    貢獻者: Natl Cheng Kung Univ,Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg
    Natl Cheng Kung Univ,Natl Cheng Kung Univ Hosp, Coll Med, Dept Biochem & Mol Biol
    Kaohsiung Med Univ,Kaohsiung Med Univ Hosp, Dept Emergency Med
    Chia Nan Univ Pharm & Sci, Senior Citizen Dev Ctr
    關鍵字: gastric cancer
    cyclin D1
    histological type
    overall survival
    progression-free survival
    日期: 2017-10
    上傳時間: 2018-11-30 15:54:57 (UTC+8)
    出版者: Spandidos Publ Ltd
    摘要: Overexpression of cyclin D is associated with the molecular tumorigenesis of gastric cancer. The purpose of the present study was to investigate the expression of cyclin D in human gastric cancer and to determine the potential correlations between cyclin D expression and clinicopathological characteristics of specific histological types, as well as its prognostic significance. In the present study, the expression of the cyclin D1 (CCND1), cyclin D2 (CCND2) and cyclin D3 (CCND3) genes in gastric cancer patients was explored using the Oncomine database, and their correlation with overall survival (OS) and progression-free survival (PFS) was evalua-ted using Kaplan-Meier analysis. The prognostic significance of CCND1 protein expression was evaluated by western blot analysis of 32 matched specimens of gastric adenocarcinomas and normal tissues obtained from patients treated at the National Cheng Kung University Hospital (Tainan, Taiwan). Analysis of the Oncomine cancer microarray database revealed that CCND1 gene expression was significantly increased in gastric intestinal-type adenocarcinoma, while CCND2 was significantly increased in diffuse gastric adenocarcinoma, gastric intestinal-type adenocarcinoma and gastric mixed adenocarcinoma. Kaplan-Meier analysis indicated that overexpression of CCND1 was associated with reduced OS and PFS. In addition, overexpression of CCND1 and downregulation of CCND2 were significantly correlated with receptor tyrosine-protein kinase erb-2-negative tumors and poor differe-ntiation. The ratio of relative CCND1 expression (expressed as the CCND1/beta-actin ratio) in tumor tissues compared with that in normal tissues was correlated with poor differentiation (P=0.0018). In summary, CCND1 overexpression is associated with shorter survival in patients with gastric cancer and with poorly differentiated tumors.
    關聯: Oncology Letters, v.14, n.4, pp.4517-4526
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