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    標題: 2-Adamantanamine produces prolonged spinal block in rats
    作者: Chen, Yu-Wen
    Chen, Chia-Ming
    Liu, Kuo-Sheng
    Wang, Jhi-Joung
    Hung, Ching-Hsia
    貢獻者: Chi Mei Med Ctr, Dept Med Res
    China Med Univ, Dept Phys Therapy, Coll Hlth Care
    China Med Univ, Grad Inst Rehabil Sci, Coll Hlth Care
    Chi Mei Med Ctr, Dept Anesthesiol
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Natl Cheng Kung Univ, Dept Phys Therapy, Coll Med
    Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci
    關鍵字: Intrathecal injection
    2-adamantanamine
    Mepivacairie
    Nociception
    Proprioception
    Motor function
    日期: 2017-06-13
    上傳時間: 2018-11-30 15:54:48 (UTC+8)
    出版者: Elsevier Ireland Ltd
    摘要: We aimed to investigate the local anesthetic effect of 2-adamantanamine in spinal anesthesia. The dose-response curves were constructed after intrathecally injecting the rats with five doses of 2-adamantanamine and a common local anesthetic mepivacaine. The quality and duration of 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block were compared with that of mepivacaine. We revealed that 2-adamantanamine provoked spinal nociceptive, proprioceptive and motor block dose-dependently. On the 50% effective dose (ED50) basis, the rank of potency was mepivacaine > 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block (p < 0.05 for the differences). 2-Adamantanamine, but not mepivacaine produced more nociceptive block than motor block (p < 0.05). At the equianesthetic doses (ED75, ED50, and ED25), the nociceptive block duration caused by 2-adamantanamine was greater than that caused by mepivacaine (p < 0.01 for the differences). These preclinical data showed that 2-adamantanamine is less potent than mepivacaine, while 2-adamantanamine provokes greater duration of spinal nociceptive block than mepivacaine. Furthermore, 2-adamantanamine demonstrates a more nociceptive-selective action over motor block. (C) 2017 Elsevier B.V. All rights reserved.
    關聯: Neuroscience Letters, v.653, pp.168-172
    顯示於類別:[藥學系(所)] 期刊論文

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