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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31735

    標題: Infection-related hospitalization and risk of end-stage renal disease in patients with systemic lupus erythematosus: a nationwide population-based study
    作者: Lin, Chien-Hung
    Hung, Peir-Haur
    Hu, Hsiao-Yun
    Chen, Yann-Jang
    Guo, How-Ran
    Hung, Kuan-Yu
    貢獻者: Natl Yang Ming Univ, Inst Clin Med
    Taipei City Hosp, Zhongxing Branch, Dept Pediat
    Ditmanson Med Fdn, Dept Internal Med,Chia Yi Christian Hosp
    Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
    Taipei City Hosp, Dept Educ & Res
    Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Coll Med
    Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
    Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch
    關鍵字: end-stage renal disease
    National Health Insurance
    systemic lupus erythematosus
    日期: 2017-10
    上傳時間: 2018-11-30 15:54:44 (UTC+8)
    出版者: Oxford Univ Press
    摘要: Background. Infections are a major cause of morbidity in patients with systemic lupus erythematosus (SLE), and may lead to death. No nationally representative study of patients with SLE has examined the rates of infection-related hospitalization and the risk of end-stage renal disease (ESRD). Methods. We conducted a nationwide cohort study of 7326 patients with newly diagnosed SLE and no history of ESRD. All data were from Taiwan's National Health Insurance claims database for the period 2000-11. Results. Among all SLE patients, 316 (4.3%) developed ESRD (mean follow-up time: 8.1 years). Multivariate Cox regression analysis indicated that the risk of ESRD increased with the number of infection-related hospitalizations. For patients with three or more infection-related admissions, the hazard ratio (HR) for ESRD was 5.08 [95% confidence interval (CI): 3.74-6.90] relative to those with no infection-related admission. Analysis by type of infection indicated that bacteremia patients had the greatest risk for ESRD (HR: 4.82; 95% CI: 3.40-6.85). Analysis of age of SLE onset indicated that patients with juvenile-onset (< 18 years) and three or more infection-related hospitalizations had a greatly increased risk for ESRD (HR: 14.49; 95% CI: 5.34-39.33). Conclusions. Infection-related hospitalizations are associated with a significantly increased risk of ESRD in patients with SLE, especially those with juvenile-onset SLE. Among patients with different types of infectious diseases, those with bacteremia were more likely to develop ESRD.
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