Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis

doi:10.3390/molecules22060967

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標題:	Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis
作者:	Kuo, Ping-Chung Liao, Yu-Ren Hung, Hsin-Yi Chuang, Chia-Wei Hwang, Tsong-Long Huang, Shiow-Chyn Shiao, Young-Ji Kuo, Daih-Huang Wu, Tian-Shung
貢獻者:	Natl Cheng Kung Univ, Sch Pharm, Coll Med Natl Cheng Kung Univ, Dept Chem Chang Gung Univ, Grad Inst Nat Prod, Coll Med Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol Chang Gung Mem Hosp, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Pharm Natl Res Inst Chinese Med, Div Basic Chinese Med, Minist Hlth & Welf Tajen Univ, Dept Pharm, Coll Pharm & Hlth Care
關鍵字:	Citrus grandis chromatographic method spectroscopic elucidation superoxide anion generation elastase release neuroprotective
日期:	2017-06
上傳時間:	2018-11-30 15:54:35 (UTC+8)
出版者:	Mdpi Ag
摘要:	A series of chromatographic separations performed on the ethanol extracts of the peels of Citrus grandis has led to the characterization of forty compounds, including seventeen coumarins, eight flavonoids, two triterpenoids, four benzenoids, two steroids, one lignan, one amide, and five other compounds, respectively. The chemical structures of the purified constituents were identified on the basis of spectroscopic elucidation, including 1D- and 2D-NMR, UV, IR, and mass spectrometric analysis. Most of the isolated compounds were examined for their inhibition of superoxide anion generation and elastase release by human neutrophils. Among the isolates, isomeranzin (3), 17,18-dihydroxybergamottin (12), epoxybergamottin (13), rhoifolin (19), vitexicarpin (22) and 4-hydroxybenzaldehyde (29) displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values ranged from 0.54 to 7.57 mu M, and 0.43 to 4.33 mu M, respectively. In addition, 7-hydroxy-8-(2'-hydroxy-3'-methylbut-3'-enyl)coumarin (8) and 17,18-dihydroxybergamottin (12) also exhibited the protection of neurons against A beta-mediated neurotoxicity at 50 mu M.
關聯:	Molecules, v.22, n.6, pp.967
显示于类别:	[藥學系(所)] 期刊論文

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