Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis

doi:10.3390/molecules22060967

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/31731

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Title:	Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis
Authors:	Kuo, Ping-Chung Liao, Yu-Ren Hung, Hsin-Yi Chuang, Chia-Wei Hwang, Tsong-Long Huang, Shiow-Chyn Shiao, Young-Ji Kuo, Daih-Huang Wu, Tian-Shung
Contributors:	Natl Cheng Kung Univ, Sch Pharm, Coll Med Natl Cheng Kung Univ, Dept Chem Chang Gung Univ, Grad Inst Nat Prod, Coll Med Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol Chang Gung Mem Hosp, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Pharm Natl Res Inst Chinese Med, Div Basic Chinese Med, Minist Hlth & Welf Tajen Univ, Dept Pharm, Coll Pharm & Hlth Care
Keywords:	Citrus grandis chromatographic method spectroscopic elucidation superoxide anion generation elastase release neuroprotective
Date:	2017-06
Issue Date:	2018-11-30 15:54:35 (UTC+8)
Publisher:	Mdpi Ag
Abstract:	A series of chromatographic separations performed on the ethanol extracts of the peels of Citrus grandis has led to the characterization of forty compounds, including seventeen coumarins, eight flavonoids, two triterpenoids, four benzenoids, two steroids, one lignan, one amide, and five other compounds, respectively. The chemical structures of the purified constituents were identified on the basis of spectroscopic elucidation, including 1D- and 2D-NMR, UV, IR, and mass spectrometric analysis. Most of the isolated compounds were examined for their inhibition of superoxide anion generation and elastase release by human neutrophils. Among the isolates, isomeranzin (3), 17,18-dihydroxybergamottin (12), epoxybergamottin (13), rhoifolin (19), vitexicarpin (22) and 4-hydroxybenzaldehyde (29) displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values ranged from 0.54 to 7.57 mu M, and 0.43 to 4.33 mu M, respectively. In addition, 7-hydroxy-8-(2'-hydroxy-3'-methylbut-3'-enyl)coumarin (8) and 17,18-dihydroxybergamottin (12) also exhibited the protection of neurons against A beta-mediated neurotoxicity at 50 mu M.
Relation:	Molecules, v.22, n.6, pp.967
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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