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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31702


    標題: Outcomes of patients with severe influenza infection admitted to intensive care units: a retrospective study in a medical centre
    作者: Chao, Chien-Ming
    Lai, Chih-Cheng
    Chan, Khee-Siang
    Cheng, Kuo-Chen
    Chou, Willy
    Yuan, Kuo-Shu
    Chen, Chin-Ming
    貢獻者: Chi Mei Med Ctr, Dept Intens Care Med
    Chi Mei Med Ctr, Dept Intens Care Med
    Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm
    Chi Mei Med Ctr, Dept Internal Med
    Chia Nan Univ Pharm & Sci, Dept Recreat & Hlth Care Management
    Chi Mei Med Ctr, Dept Med Res
    Natl Sun Yat Sen Univ, Dept Business Management
    關鍵字: Respiratory-Distress-Syndrome
    Critically-Ill Patients
    Risk-Factors
    Critical Illness
    H1N1 Influenza
    Complications
    Resuscitation
    Impact
    Virus
    日期: 2017-10
    上傳時間: 2018-11-30 15:53:30 (UTC+8)
    出版者: Microbiology Soc
    摘要: Purpose. This study assessed clinical manifestations and prognostic factors of critically ill patients with severe influenza admitted to the intensive care unit (ICU) in Taiwan's recent outbreak. Methodology. Patients admitted to ICU for severe influenza between January 1, 2015, and March 31, 2016, were identified and their medical records were retrospectively reviewed. The primary endpoints were outcomes and predictors of in-hospital mortality. Results. There were 125 patients with an average Acute Physiology and Chronic Health Evaluation II (APACHE II) score of 20.8. Hypertension (62.4 %) and diabetes mellitus (40.8 %) were the two most common underlying diseases. Ninety-eight (78.4 %) patients had at least one organ failure: the lungs were the most common (71.2 %), followed by the heart (53.6 %). Two of the most common symptoms of patients at ICU admission were fever (68.0 %) and cough (78.4 %). Thirty-three patients (26.4 %) died; most (40.9 %) were middle-aged (50-65 years old). A Cox regression analysis showed that multiple organ failure (MOF) [ hazard ratio (HR)=3.618; 95% CI=1.058-13.662] was significantly associated with higher risk of death. In contrast, a fluid-negative balance within 7 days of admission (HR=0.362; 95% CI=0.140-0.934) was significantly associated with a lower risk of death. Conclusion. The mortality rate of severe influenza patients admitted to the ICU was high, especially in middle-aged adults. The risk of mortality was associated with >= 2 organ failures. A negative fluid balance predicts survival.
    關聯: Journal of Medical Microbiology, v.66, n.10, pp.1421-1428
    Appears in Collections:[休閒保健管理系(所)] 期刊論文

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