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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31697


    標題: Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases
    作者: Chen, Rong-Jane
    Lee, Yu-Hsuan
    Yeh, Ya-Ling
    Wu, Wun-Syuan
    Ho, Chi-Tang
    Li, Chia-Yi
    Wang, Bour-Jr
    Wang, Ying-Jan
    貢獻者: Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Coll Med
    Rutgers State Univ, Dept Food Sci
    Robert Thirsk High Sch, Calgary
    Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
    Asia Univ, Dept Biomed Informat
    China Med Univ,China Med Univ Hosp, Dept Med Res
    Taipei Med Univ, Grad Inst Clin Med
    關鍵字: autophagy
    inflammation
    pterostilbene
    skin disorders
    日期: 2017-01
    上傳時間: 2018-11-30 15:53:16 (UTC+8)
    出版者: Food & Drug Adminstration
    摘要: Pterostilbene is a naturally occurring analog of resveratrol with many health benefits. These health benefits are associated with its antioxidant activity, anti-inflammatory effects, and chemopreventive effects attributed to its unique structure. The skin cancer chemopreventive potential of pterostilbene is supported by a variety of mechanistic studies confirming the anti-inflammatory effects in skin cancer models. Molecular biological studies have identified that pterostilbene targets pleotropic signaling pathways, including those involved in mitogenesis, cell cycle regulation, and apoptosis. Recently, pterostilbene has been reported to induce autophagy in cancer and normal cells. Through autophagy induction, the inflammatory-related skin diseases can be attenuated. This finding suggests the potential use of pterostilbene in the treatment and prevention of skin disorders via alleviating inflammatory responses by autophagy induction. This review summarizes the protective and therapeutic benefits of pterostilbene in skin diseases from the viewpoint of its antioxidant, anti-inflammatory, and autophagy-inducing effects. Novel underlying mechanisms regarding these effects are discussed. We proposed that pterostilbene, a promising natural product, can be used as a preventive and therapeutic agent for inflammation-related skin disorders through induction of autophagy. Copyright (C) 2016, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
    關聯: Journal of Food and Drug Analysis, v.25, n.1, pp.125-133
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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