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    標題: High Expression of Aldolase B Confers a Poor Prognosis for Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy
    作者: Tian, Yu-Feng
    Hsieh, Pei-Ling
    Lin, Ching-Yih
    Sun, Ding-Ping
    Sheu, Ming-Jen
    Yang, Ching-Chieh
    Lin, Li-Ching
    He, Hong-Lin
    Solorzano, Julia
    Li, Chien-Feng
    Chang, I-Wei
    貢獻者: Chi Mei Med Ctr, Dept Surg, Div Gen Surg
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chi Mei Med Ctr, Dept Med Image
    Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol
    Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Chi Mei Med Ctr, Dept Radiat Oncol
    I Shou Univ, E DA Hosp, Dept Pathol
    I Shou Univ, Sch Med
    Chi Mei Med Ctr, Dept Pathol
    Natl Hlth Res Inst, Natl Inst Canc Res
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Kaohsiung Med Univ, Inst Clin Med
    關鍵字: ALDOB
    Aldolase B
    CCRT
    chemoradiotherapy
    rectal cancer
    日期: 2017
    上傳時間: 2018-11-30 15:52:52 (UTC+8)
    出版者: Ivyspring Int Publ
    摘要: Background: Colorectal cancer is the third most common cancer in both sex worldwide and it is also the fourth most common cause of cancer mortality. For rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) followed by radical proctectomy is gold standard treatment for patients with stage II/III rectal cancer. By data mining a documented database of rectal cancer transcriptome (GSE35452) from Gene Expression Omnibus, National Center of Biotechnology Information, we recognized that ALDOB was the most significantly up-regulated transcript among those related to glycolysis (GO: 0006096). Hence, we analyzed the clinicopathological correlation and prognostic effect of ALDOB protein (Aldolase B), which encoded by ALDOB gene. Methods: ALDOB immunostain was performed in 172 rectal adenocarcinomas treated with preoperative chemoradiotherapy followed by radical surgery, which were divided into high-and low-expression groups. Furthermore, statistical analyses were examined to correlate the relationship between ALDOB immunoreactivity and important clinical and pathological characteristics, as well as three survival indices: disease-specific survival (DSS), local recurrence-free survival (LRFS) and metastasis-free survival (MeFS). Results: ALDOB (Aldolase B) over-expression was significantly associated with pre-CCRT and post-CCRT tumor advancement, lymphovascular invasion, perineural invasion and poor response to CCRT (all P <= .023). In addition, ALDOB high expression was linked to adverse DSS, LRFS and MeFS in univariate analysis (P <= .0075) and also served as an independent prognosticator indicating dismal DSS and MeFS in multivariate analysis (hazard ratio (HR) = 3.462, 95% confidence interval (CI): 1.263-9.495; HR = 2.846, 95% CI: 1.190-6.808, respectively). Conclusion: ALDOB (Aldolase B) may play an imperative role in rectal cancer progression and responsiveness to neoadjuvant CCRT, and serve as a novel prognostic biomarker. Additional researches to clarify the molecular and biochemical pathways are essential for developing promising ALDOB-targeted therapies for patients with rectal cancers.
    關聯: Journal of Cancer, v.8, n.7, pp.1197-1204
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