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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31669


    標題: Anti-Inflammatory Activity and Bioactive Constituents of Cultivated Fruiting Bodies of Xylaria nigripes (Ascomycetes), a Chinese Medicinal Fungus
    作者: Liaw, Chih-Chuang
    Wu, Shu-Jing
    Chen, Ching-Fu
    Lai, Ming-Nan
    Ng, Lean-Teik
    貢獻者: Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Natl Taiwan Univ, Dept Agr Chem
    Kang Jian Biotech Co Ltd
    關鍵字: anti-inflammatory
    bioactive compounds
    medicinal mushroom
    Xylaria nigripes
    日期: 2017
    上傳時間: 2018-11-30 15:52:15 (UTC+8)
    出版者: Begell House Inc
    摘要: Xylaria nigripes, also known as Wu Ling Shen, is popular for treating insomnia and trauma in traditional Chinese medicine. This study aimed to examine the anti-inflammatory activity and bioactive constituents of cultivated X. nigripes fruiting bodies in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Results showed that among the different extracts, the hexane fraction exhibited the best protection against cell toxicity induced by 1 mu g/mL LPS and the strongest inhibitory effect on nitric oxide (NO) production. This fraction led to the isolation of 2 bioactive compounds (namely, XN-CP1 and XN-CP2), which were confirmed to be ergostarien-3 beta-ol and ergosterol peroxide, respectively. Although both XN-CP1 and XN-CP2 showed good inhibitory effects on NO, tumor necrosis factor-a, interleukin (IL)-1 beta, IL-6, and prostaglandin E-2 production in LPS-stimulated macrophages, XN-CP2 was shown to have a stronger anti-inflammatory activity; this was further supported by its strong suppressive effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and nuclear factor (NF)-kappa B activation. These results conclude that ergosterol peroxide (XN-CP2) could be the main bioactive compound contributing to the potent anti-inflammatory activity of X. nigripes, and its mechanism of action is mediated through inhibition of iNOS and COX-2 expression via the NF-kappa B signaling pathway.
    關聯: International Journal of Medicinal Mushrooms, v.19, n.10, pp.915-924
    Appears in Collections:[保健營養系(所) ] 期刊論文

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