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    請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/31644

    標題: Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells
    作者: Wang, Wen-Hung
    Hsuan, Kuo-Yu
    Chu, Ling-Ya
    Lee, Chia-Ying
    Tyan, Yu-Chang
    Chen, Zong-Shiow
    Tsai, Wan-Chi
    貢獻者: Cathay Gen Hosp, Dept Otolaryngol
    SijhihCathay Gen Hosp, Dept Otolaryngol
    Fu Jen Catholic Univ, Sch Med
    Chi Mei Med Ctr, Dept Hematooncol
    Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol
    Kaohsiung Med Univ, Dept Med Imaging & Radiol Sci
    Kaohsiung Med Univ, Ctr Infect Dis & Canc Res
    Kaohsiung Med Univ, Coll Med, Grad Inst Med
    Natl Sun Yat Sen Univ, Inst Med Sci & Technol
    Kaohsiung Med Univ Hosp, Dept Med Res
    Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
    關鍵字: In-Vitro
    Tanshinone Iia
    日期: 2017
    上傳時間: 2018-11-30 15:51:20 (UTC+8)
    出版者: Hindawi Ltd
    摘要: Researchers have reported significant effects from Danshen (Salvia miltiorrhiza) in terms of inhibiting tumor cell proliferation and promoting apoptosis in breast cancer, hepatocellular carcinomas, promyelocytic leukemia, and clear cell ovary carcinomas. Here we report our data indicating that Danshen extracts, especially alcohol extract, significantly inhibited the proliferation of the human oral squamous carcinoma (OSCC) cell lines HSC-3 and OC-2. We also observed that Danshen alcohol extract activated the caspase-3 apoptosis executor by impeding members of the inhibitor of apoptosis (IAP) family, but not by regulating the Bcl-2-triggered mitochondrial pathway in OSCC cells. Our data also indicate that the extract exerted promising effects in vivo, with HSC-3 tumor xenograft growth being suppressed by 40% and 69% following treatment with Danshen alcohol extract at 50 and 100mg/kg, respectively, for 34 days. Combined, our results indicate appreciable anticancer activity and significant potential for Danshen alcohol extract as a natural antioxidant and herbal human oral cancer chemopreventive drug.
    關聯: Evidence-Based Complementary and Alternative Medicine, v.2017, 文獻號碼:5364010
    顯示於類別:[化妝品應用與管理系(所)] 期刊論文


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