Effect of enterovirus infections on asthma in young children: Anational cohort study

doi:10.1111/eci.12844

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Title:	Effect of enterovirus infections on asthma in young children: Anational cohort study
Authors:	Yeh, Jun-Jun Lin, Cheng-Li Hsu, Wu-Huei
Contributors:	Chia Yi Christian Hosp, Dept Family Med,Ditmanson Med Fdn Chia Nan Univ Pharm & Sci Meiho Univ China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med China Med Univ, Grad Inst Clin Med Sci, Coll Med China Med Univ, Sch Med, Coll Med China Med Univ Hosp, Div Pulm & Crit Care Med, Dept Internal Med
Keywords:	asthma cohort study enterovirus
Date:	2017-12
Issue Date:	2018-11-30 15:51:16 (UTC+8)
Publisher:	Wiley
Abstract:	BackgroundWe conducted a cohort study to determine the relationship between enterovirus (EV) infection and asthma. Materials and methodsFrom the National Health Insurance Research Database of Taiwan, we identified patients who received a new diagnosis of asthma and concurrent treatment between January 2000 and December 2011 (EV cohort: n=208213; non-EV cohort: n=208213). Cox proportional hazards regression analysis was performed to determine and compare the adjusted hazard ratios (aHRs) of asthma between these 2 cohorts. Kaplan-Meier analysis was conducted to assess the differences in the cumulative incidence curves of asthma between the 2 cohorts. ResultsThe overall aHR of asthma was 1.48-fold higher in the EV cohort than in the non-EV cohort (95% confidence interval=1.45-1.50). The aHR of asthma was higher in the EV cohort than in the non-EV cohort, comprising children aged 5years, regardless of sex, sociodemographic factors (urbanization level and parental occupation) or comorbidities. The risk of asthma was higher in 1-3, 4-6, 7-9 and 10-12months (all P<.001), particularly in those with a higher frequency of admission (>5 per year). ConclusionThe incidence of asthma was higher in the EV cohort than in the non-EV cohort, comprising children aged 5years, regardless of sex, urbanization level, parental occupation or season. In particular, the risk of asthma was higher in children with a higher frequency of admission, even in the absence of atopy or other respiratory infections.
Relation:	European Journal of Clinical Investigation, v.47, n.12, 文獻號碼:UNSP e12844
Appears in Collections:	[Dept. of Childhood Education and Nursery] Periodical Articles

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