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    標題: Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents
    作者: Reddy, Mopur Vijaya Bhaskar
    Hung, Hsin-Yi
    Kuo, Ping-Chung
    Huang, Guan-Jhong
    Chan, Yu-Yi
    Huang, Shiow-Chyn
    Wu, Shwu-Jen
    Morris-Natschke, Susan L.
    Lee, Kuo-Hsiung
    Wu, Tian-Shung
    貢獻者: Natl Cheng Kung Univ,Natl Cheng Kung Univ Hosp, Coll Med, Sch Pharm
    China Med Univ, Coll Pharm, Sch Chinese Pharmaceut Sci & Chinese Med Resource
    South Taiwan Univ Sci & Technol, Dept Biotechnol
    Chia Nan Univ Pharm & Sci, Grad Inst Pharmaceut Sci
    Chung Hua Univ Med Technol, Dept Med Technol
    Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs
    China Med Univ,China Med Univ Hosp, Chinese Med Res & Dev Ctr
    Tajen Univ, Coll Pharm & Hlth Care, Dept Pharm
    關鍵字: Chalcones
    Dihydrochalcones
    1,3-Diarylpropane analogs
    Anti-inflammatory agents
    日期: 2017-04-01
    上傳時間: 2018-11-30 15:49:48 (UTC+8)
    出版者: Pergamon-Elsevier Science Ltd
    摘要: Twenty-one chalcones were prepared via aldol condensation and subsequent reduction of these compound led to the corresponding dihydrochalcone and 1,3-diphenylpropane derivatives. The synthetic products were examined for their effects on NO inhibition in LPS-activated mouse peritoneal macrophages. Among the tested compounds, a 1,3-diarylpropane analog, 2-(3-(3,4-dimethoxyphenyl)propyl)5-methoxyphenol (3p), displayed the most significant inhibitory effects against NO production. To investigate the mechanism of action, the effects of 3p on iNOS and COX-2 protein expression were studied by immunoblot. The results concluded that 3p is capable of inhibiting iNOS expression in LPS-induced RAW264.7 cells via attenuation of NF-kappa B signaling by ERIC, p38, and JNK. (C) 2017 Elsevier Ltd. All rights reserved.
    關聯: Bioorganic & Medicinal Chemistry Letters, v.27, n.7, pp.1547-1550
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