Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31360
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    CNU IR > Pharmacy and Science > 2016 >  Item 310902800/31360
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    Title: Benzodiazepinedione 衍生物的合成研究
    Authors: 許睿晴
    Contributors: 嘉南藥理大學醫藥化學系
    Date: 2016-05-10
    Issue Date: 2018-05-21 10:35:19 (UTC+8)
    Abstract: 本研究將以不同官能基的2-胺基苯甲酸(2-amino- benzoic acid)為起始物,與Bis(trichloromethyl) carbonate 進行環化反應,形成不同官能基的isatoic anhydride 後,再與色胺酸(L-Tryptophan)進行胺基酸反應,合成不同的Benzodiazepinedione。除了作為acetylaszonalenin 的生合成的前驅物外,預期將表現生物活性潛能,有進一步產品開發價值。
    具有Benzodiazepinedione 骨架之化合物除有鎮靜、安眠之中樞神經作用外,在某些研究中發現其亦能表現出抗癌與抗菌活性,是一種具多樣生物活性的化學結構。
    Relation: 2016 第十屆嘉南藥理大學藥理學院師生研究成果發表會,起迄日:2016/05/10-2016/05/13,地點:嘉南藥理大學國際會議中心一樓
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Proceedings
    [Dept. of Medicinal Chemistry] Proceedings
    [Pharmacy and Science] 2016

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