Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31352
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    CNU IR > Pharmacy and Science > 2016 >  Item 310902800/31352
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31352


    Title: Sildenafil reduces signs of oxidative stress in pulmonary arterial hypertension: Evaluation by fatty acid composition, level of hydroxynonenal and heart rate variability
    Authors: 石聖玄
    Contributors: 嘉南藥理大學藥學系
    方嘉德
    Keywords: Pulmonary arterial hypertension
    Sildenafil
    Hydroxynonenal
    Fatty acid composition
    Heart rate variability
    Date: 2016-05-10
    Issue Date: 2018-05-21 10:35:10 (UTC+8)
    Abstract: 肺動脈高壓Pulmonary arterial hypertension (PAH)是一種受多種因素影響的疾病,所以我們必須分析會影響肺動脈壓力的各種因素,才可以得知 Sildenafil藥物治療對人體產生的益處或影響。肺動脈高壓的病人心肺血管擁有較高的氧化性壓力oxidative stress,主要生理上會有羥基壬hydroxynonenal(HNE)數值較高,還有磷脂質中的脂肪酸fatty acids (FAs)濃度增加,心率變化率增加等。然而,肺動脈高壓產生的負面影響如血管的收縮或舒張程度,血管的好壞或者血管的氧化性壓力無法直接由觀測所得,但是我們卻可以評估Sildenafil 藥物治療後,使某些代表性的體內升數值的增高或降低,評估的有脂肪酸fatty acids (Fas) status, 羥基壬。
    hydroxynonenal (HNE)水平和心率變化性heart rate variability (HRV)。
    Relation: 2016 第十屆嘉南藥理大學藥理學院師生研究成果發表會,起迄日:2016/05/10-2016/05/13,地點:嘉南藥理大學國際會議中心一樓
    Appears in Collections:[Dept. of Pharmacy] Proceedings
    [Pharmacy and Science] 2016

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