The physical stability study of preparation and process optimization of semi solid dosage forms

CNU IR > Pharmacy and Science > 2016 > Item 310902800/31310

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Title:	The physical stability study of preparation and process optimization of semi solid dosage forms
Authors:	Chong-De Lee Hung-Hong Lin
Contributors:	嘉南藥理大學藥學系
Keywords:	Semi solid dosage form Physical stability Optimization
Date:	2016-05-10
Issue Date:	2018-05-21 10:34:23 (UTC+8)
Abstract:	Objectives: Topical semi-solid dosage forms contain one or more active ingredients dissolved or uniformly dispersed in a suitable base and any suitable excipients. The main stability problems observed in base are bleeding and change in consistency due to aging. The study was to investigate the physical stability in preparation and process optimization of the base of semi solid dosage forms. Methods: Accelerated physical stability testing is determined a noticeable change in consistency, such as excessive "bleeding" (separation of excessive amounts of liquid) or formation of agglomerates and grittiness by centrifugation. The viscosity of base is investigated by Cone and Plate Viscometer. Results: The amount of liquid added into base reaches a critical amount then the resulted preparation will begin to bleed out and will lose its viscosity. The process optimization in high shear homogenization for uniform particle size and viscosity reduction will promote the physical stability study of preparations.
Relation:	2016 第十屆嘉南藥理大學藥理學院師生研究成果發表會，起迄日：2016/05/10-2016/05/13，地點：嘉南藥理大學國際會議中心一樓
Appears in Collections:	[Dept. of Pharmacy] Proceedings [Pharmacy and Science] 2016

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