Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 藥學系(所) > 期刊論文 > Item 310902800/31081

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/31081

標題:	Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans
作者:	Lin, Tzu-Shyang Chiang, Yi-Ming Wang, Clay C. C.
貢獻者:	Univ So Calif, Sch Pharm, Dept Pharmacol & Pharmaceut Sci Chia Nan Univ Pharm & Sci, Dept Pharm Univ So Calif, Dept Chem, Coll Letters Arts & Sci
關鍵字:	gene clusters synthase methylation metabolites system fungus cells
日期:	2016-03
上傳時間:	2018-01-18 11:41:21 (UTC+8)
出版者:	Amer Chemical Soc
摘要:	Citreoviridin (1) belongs to a class of F1-ATPase beta-subunit inhibitors that are synthesized by highly reducing polyketide synthases. These potent mycotoxins share an alpha-pyrone polyene structure, and they include aurovertin, verrucosidin, and asteltoxin. The identification of the citreoviridin biosynthetic gene cluster in Aspergillus terreus var. aureus and its reconstitution using heterologous expression in Aspergillus nidulans are reported. Two intermediates were isolated that allowed the proposal of the biosynthetic pathway of citreoviridin.
關聯:	Organic Letters, v.18 n.6, pp.1366-1369
显示于类别:	[藥學系(所)] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	1221	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章