Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans

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Title:	Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans
Authors:	Lin, Tzu-Shyang Chiang, Yi-Ming Wang, Clay C. C.
Contributors:	Univ So Calif, Sch Pharm, Dept Pharmacol & Pharmaceut Sci Chia Nan Univ Pharm & Sci, Dept Pharm Univ So Calif, Dept Chem, Coll Letters Arts & Sci
Keywords:	gene clusters synthase methylation metabolites system fungus cells
Date:	2016-03
Issue Date:	2018-01-18 11:41:21 (UTC+8)
Publisher:	Amer Chemical Soc
Abstract:	Citreoviridin (1) belongs to a class of F1-ATPase beta-subunit inhibitors that are synthesized by highly reducing polyketide synthases. These potent mycotoxins share an alpha-pyrone polyene structure, and they include aurovertin, verrucosidin, and asteltoxin. The identification of the citreoviridin biosynthetic gene cluster in Aspergillus terreus var. aureus and its reconstitution using heterologous expression in Aspergillus nidulans are reported. Two intermediates were isolated that allowed the proposal of the biosynthetic pathway of citreoviridin.
Relation:	Organic Letters, v.18 n.6, pp.1366-1369
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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