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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31067

    標題: The role of doxycycline in the therapy of multidrug-resistant E. coli - an in vitro study
    作者: Lai, Chih-Cheng
    Chen, Chi-Chung
    Huang, Hui-Ling
    Chuang, Yin-Ching
    Tang, Hung-Jen
    貢獻者: Chi Mei Med Ctr, Dept Intens Care Med
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chi Mei Med Ctr, Dept Internal Med
    Chi Mei Med Ctr, Dept Med
    關鍵字: carbapenemase-producing enterobacteriaceae
    glycylcycline antimicrobial agent
    field gel-electrophoresis
    gram-negative bacteria
    combination therapy
    日期: 2016-08
    上傳時間: 2018-01-18 11:41:00 (UTC+8)
    出版者: Nature Publishing Group
    摘要: This study assessed the in vitro antibacterial activity of combinations of amikacin and doxycycline or tigecycline against multidrug-resistant E. coli isolates. Twenty-four different pulsotypes, including 10 extended-spectrum beta-lactamase (ESBL)-, 10 carbapenem-resistant, 2 New Delhi Metallo-beta-lactamase (NDM)- and 2 Klebsiella pneumoniae carbapenemase (KPC)-E. coli isolates were collected. All 24 isolates were susceptible to amikacin and tigecycline. Only 30% of ESBL and 50% of carbapenem-resistant E. coli were susceptible to doxycycline. Both of the NDM-E. coli had a MIC of 64 mu g/ml. The checkerboard method showed that for the ESBL-and carbapenem-resistant E. coli, the synergistic effects of amikacin/doxycycline were 80% and 90%, respectively. For the two KPC- and two NDM-E. coli, the FIC index of amikacin/doxycycline were 0.5/0.375 and 0.5/0.281, respectively. For the ESBL- and carbapenem-resistant E. coli isolates, the combinations of amikacin and doxycycline exhibited synergistic activities against 80%, and 80% and 10% vs 60%, and 80% and 10% of the isolates at concentrations of 1x, 1/2x and 1/4xMIC, respectively. The synergistic effect seems to be similar for doxycycline and tigecycline based combinations with amikacin. In conclusion, the antibacterial activity of doxycycline can be enhanced by the addition of amikacin and is observed against most multidrug-resistant E. coli isolates.
    關聯: Scientific Reports, v.6, 31964
    Appears in Collections:[保健營養系(所) ] 期刊論文

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