Association of Respiratory Tuberculosis with Incident Bone Fracture: Bridging the Tuberculosis Airway Infection and the Osteoporotic Bone

doi:10.1371/journal.pone.0168673

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Title:	Association of Respiratory Tuberculosis with Incident Bone Fracture: Bridging the Tuberculosis Airway Infection and the Osteoporotic Bone
Authors:	Yeh, Jun-Jun Wang, Yu-Chiao Lin, Che-Chen Lin, Cheng-Li Hsu, Wu-Huei
Contributors:	Ditmanson Med Fdn, Chia Yi Christian Hosp Chia Nan Univ Pharm & Sci,Dep. of Child Edu and Nurs Meiho Univ China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med China Med Univ, Coll Med, Grad Inst Clin Med Sci China Med Univ, Coll Med, Sch Med China Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med
Keywords:	inhaled corticosteroids mineral density high-risk metaanalysis prevention disease women taiwan health ligand
Date:	2016-12
Issue Date:	2018-01-18 11:40:44 (UTC+8)
Publisher:	Public Library Science
Abstract:	Objective The relationship between respiratory tuberculosis (RT) and incident fragility fracture and osteoporosis/fragility fracture in the general population is not well determined; therefore, we conducted a nationwide cohort study to investigate this relationship. Methods We used the National Health Insurance Research Database of Taiwan to identify 6612 newly diagnosed patients with RT (RT cohort) and 13220 patients without RT (non-RT cohort) from 1999 to 2005. The mean durations of follow-up were (6.73 +/- 4.00 years, 8.11 +/- 3.24 years) in the (RT cohort, non-RT cohort); respectively. The occurrence of incident fragility fracture and osteoporosis/fragility fracture were followed up until the end of 2011. The adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) and 98% CIs of incident fragility fracture and osteoporosis/fragility fracture were estimated using the multivariable Cox proportional hazard model after adjusting for age, sex, occupation, drug use, and comorbidities. Results A Cox proportional hazards regression analysis was performed and showed the aHRs of [incident fragility fracture; osteoporosis/fragility fracture] were [1.69 (95% CI = 1.26 +/- 2.28, 98% CI = 1.18 +/- 2.44); 1.42 (95% CI = 1.25 +/- 1.61, 98% CI = 1.21 +/- 1.65)] between the RT and non-RT cohorts. Regarding the sex, the aHRs of the [incident fragility fracture; osteoporosis /fragility fracture] were [1.57 (98% CI = 1.10 +/- 2.23, 98% CI = 1.02 +/- 2.41); 1.15 (95% CI = 0.97 +/- 1.36, 98% CI = 0.94 +/- 1.41)] in the men. The aHRs of the RT cohort without oral steroid use in the [incident fragility fracture; osteoporosis /fragility fracture] were [1.87 (95% CI = 1.20-2.90, 98% CI = 1.09-3.19); 1.41 (95% CI = 1.19-1.67, 98% CI = 1.14-1.74)]. Conclusion The RT associated with the incident fragility fracture, either in men or absence of oral steroid use.
Relation:	Plos One, v.11 n.12, e0168673
Appears in Collections:	[Dept. of Childhood Education and Nursery] Periodical Articles

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