Skin whitening capability of shikimic acid pathway compounds

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Title:	Skin whitening capability of shikimic acid pathway compounds
Authors:	Chen, Y. -H. Huang, L. Wen, Z. -H. Zhang, C. Liang, C. -H. Lai, S. -T. Luo, L. -Z. Wang, Y. -Y. Wang, G. -H.
Contributors:	Xiamen Med Coll, Dept Pharm Xiamen Med Coll, Res Ctr Nat Cosmeceut Engn Xiamen TRIZ Labs Ltd, Dept Res Engn Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Xiamen Med Coll, Dept Pharm Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr
Keywords:	Tyrosinase Zebrafish Shikimic acid pathway Shikimic acid
Date:	2016-03
Issue Date:	2018-01-18 11:40:40 (UTC+8)
Publisher:	Verduci Publisher
Abstract:	OBJECTIVE: To examine the skin whitening capabilities of shikimic acid pathway compounds and find the most effective molecule to be used as the active ingredient for skin whitening products. MATERIALS AND METHODS: Skin whitening is the practice of using chemical substances to lighten skin tone by the lessening the concentration of melanin. The whitening efficacy of shikimic acid pathway compounds was evaluated. Eight compounds in the shikimic acid pathway were chosen for this study: benzoic acid, p-coumaric acid, vanillic acid, syringic acid, quinic acid, shikimic acid, orcinol monohydrate, and phenyl pyruvic acid. We measured the tyrosinase inhibitory capacity of the compounds in the animal model of zebrafish and also evaluated the compounds' anti-oxidant activities using the DPPH radical scavenging, and ABTS+ free radical scavenging tests. Compounds' cytotoxicity effects were also evaluated. RESULTS: Amongst eight shikimic acid pathway compounds used in this study, shikimic acid was the most potent tyrosinase-inhibitor and the most efficient compound to be used as an active ingredient for skin whitening. Shikimic acid revealed a good radical scavenging activity (RAS) with low cell toxicity. CONCLUSIONS: Promising results obtained in this study may open a new window of opportunity to introduce another compound to be used in the skin-whiting cosmetics industry.
Relation:	European Review For Medical and Pharmacological Sciences, v.20 n.6, pp.1214-1220
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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