Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31028
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    Title: Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study
    Authors: Yeh, Jun-Jun
    Wang, Yu-Chiao
    Hsu, Wu-Huei
    Kao, Chia-Hung
    Contributors: Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Chest Med & Family Med
    Chia Nan Univ Pharm & Sci
    Meiho Univ
    China Med Univ Hosp, Management Off Hlth Data
    China Med Univ Hosp, Sch Med
    China Med Univ Hosp, Grad Inst Clin Med Sci
    China Med Univ Hosp, Coll Med, Sch Med
    China Med Univ Hosp, Dept Nucl Med
    China Med Univ Hosp, PET Ctr
    Keywords: Mycoplasma pneumoniae
    asthma
    antibiotic
    steroid
    cohort study
    surveillance
    Date: 2016-04
    Issue Date: 2018-01-18 11:40:09 (UTC+8)
    Publisher: Mosby-Elsevier
    Abstract: Background: Previous studies investigating the relationship between Mycoplasma pneumoniae and incident asthma in the general population have been inconclusive. Objective: We conducted a nationwide cohort study to clarify this relationship. Methods: Using the National Health Insurance Research Database of Taiwan, we identified 1591 patients with M pneumoniae infection (International Classification of Diseases, Ninth Revision, Clinical Modification code 4830) given diagnoses between 2000 and 2008. We then frequency matched 6364 patients without M pneumoniae infection from the general population according to age, sex, and index year. Cox proportional hazards regression analysis was performed to determine the adjusted hazard ratio (aHR) of the occurrence of asthma in the M pneumoniae cohort compared with that in the non-M pneumoniae cohort. Results: Regardless of comorbidities and the use of antibiotic or steroid therapies, patients with M pneumonia infection had a higher risk of incident asthma than those without it. The aHR of asthma was 3.35 (95% CI, 2.71-4.15) for the M pneumoniae cohort, with a significantly higher risk when patients were stratified by age, sex, follow-up time, and comorbidities, including allergic rhinitis, atopic dermatitis, or allergic conjunctivitis. Patients with M pneumoniae infection had a higher risk of having early-onset (age, <12 years; aHR, 2.87) and late-onset (age, >= 12 years; aHR, 3.95) asthma. The aHR was also higher within the less than 2-year follow-up in the M pneumoniae cohort (aHR, 4.41; 95% CI, 3.40-5.74) than in the cohort without the infection. Conclusion: This study found that incident cases of early-onset and late-onset asthma are closely related to M pneumoniae infection, even in nonatopic patients.
    Appears in Collections:[Dept. of Childhood Education and Nursery] Periodical Articles

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