Curcumin analog L3 alleviates diabetic atherosclerosis by multiple effects

doi:10.1016/j.ejphar.2016.02.016

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標題:	Curcumin analog L3 alleviates diabetic atherosclerosis by multiple effects
作者:	Zheng, Bin Yang, Liu Wen, Caixia Huang, Xiuwang Xu, Chenxia Lee, Kuan-Han Xu, Jianhua
貢獻者:	Fujian Med Univ, Sch Pharm, Dept Pharmacol Fuijan Prov Key Lab Nat Med Pharmacol Fujian Med Univ, Union Hosp, Dept Pharm Fujian Med Univ, Sch Pharm, Dept Med Chem Chia Nan Univ Pharm & Sci, Sch Pharm
關鍵字:	L3 Analog of curcumin Diabetic atherosclerosis Dyslipidemia Hyperglycemia
日期:	2016-03
上傳時間:	2018-01-18 11:40:01 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	L3, an analog of curcumin, is a compound isolated from a traditional Chinese medicine Turmeric. In this paper, we aims to explore the efficacy of L3 on diabetic atherosclerosis and the related mechanism. The effect of L3 was studied on glucose and lipid metabolism, antioxidant status, atherosclerosis-related indexes and pathological changes of main organs in the mice model of diabetes induced by streptozotocin and high-fat diet. The results showed that L3 treatment could meliorate dyslipidemia and hyperglycemia, reduce oxidative stress, enhance the activity of antioxidases, increase the nitric oxide level in plasma and aortic arch, decrease the production of reactive oxygen species in pancreas and lectin-like oxidized low-density lipoprotein receptor-1 expression in aortic arch, and meliorate the fatty and atherosclerotic degeneration in aortic arch, thereby preventing the development of diabetes and its complications. These results suggested that L3 can alleviate the diabetic atherosclerosis by multiple effects. This study provided scientific basis for the further research and clinical application of L3. (C) 2016 Elsevier B.V. All rights reserved.
關聯:	European Journal of Pharmacology, v.775, pp.22-34
显示于类别:	[藥學系(所)] 期刊論文

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