Role of galectin-1 in urinary bladder urothelial carcinoma cell invasion through the JNK pathway

doi:10.1111/cas.13016

Chia Nan University of Pharmacy & Science Institutional Repository > 智慧生活學院 > 高齡福祉養生管理系 > 期刊論文 > Item 310902800/31003

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標題:	Role of galectin-1 in urinary bladder urothelial carcinoma cell invasion through the JNK pathway
作者:	Shen, Kun-Hung Li, Chien-Feng Chien, Lan-Hsiang Huang, Cheng-Hao Su, Chia-Cheng Liao, Alex C. Wu, Ting-Feng
貢獻者:	Southern Taiwan Univ Sci & Technol, Dept Biotechnol Chi Mei Med Ctr, Dept Urol Taipei Med Univ, Dept Urol Chi Mei Med Ctr, Dept Pathol Natl Sun Yat Sen Univ, Inst Biomed Sci Natl Hlth Res Inst, Natl Inst Canc Res Nan Pao Resins Chem Co Ltd Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
關鍵字:	Galectin-1 invasion JNK shRNA urothelial bladder urinary carcinoma
日期:	2016-10
上傳時間:	2018-01-18 11:39:37 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	Human galectin-1 is a member of the galectin family, proteins with conserved carbohydrate-recognition domains that bind galactoside. Galectin-1 is highly expressed in various tumors and participates in various oncogenic processes. However, detailed descriptions of the function of galectin-1 in urinary bladder urothelial carcinoma have not been reported. Our previous cohort investigation showed that galectin-1 is associated with tumor invasiveness and is a possible independent prognostic marker of urinary bladder urothelial carcinoma. The present study aimed to clarify the relevance of galectin-1 expression level to tumor progression and invasion. In order to decipher a mechanism for the contribution of galectin-1 to the malignant behavior of urinary bladder urothelial carcinoma, two bladder cancer cell lines (T24 and J82) were established with knockdown of galectin-1 expression by shRNA. Bladder cancer cells with LGALS1 gene silencing showed reduced cell proliferation, lower invasive capability, and lower clonogenicity. Extensive signaling pathway studies indicated that galectin-1 participated in bladder cancer cell invasion by mediating the activity of MMP9 through the Ras-Rac1-MEKK4-JNK-AP1 signaling pathway. Our functional analyses of galectin-1 in urinary bladder urothelial carcinoma provided novel insights into the critical role of galectin-1 in tumor progression and invasion. These results revealed that silencing the galectin-1-mediated MAPK signaling pathway presented a novel strategy for bladder cancer therapy.
關聯:	Cancer Science, v.107 n.10, pp.1390-1398
显示于类别:	[高齡福祉養生管理系] 期刊論文

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