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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30993


    標題: Determination of Nicotinic Acid and Metabolites in Urine, Cosmetics, and Pharmaceuticals by High-Performance Liquid Chromatography with Novel Electrochemical Detection
    作者: Wang, Lai-Hao
    貢獻者: Chia Nan Univ Pharm & Sci, Dept Med Chem
    關鍵字: Electrochemical detector
    high-performance liquid chromatography
    nicotinic acid
    日期: 2016
    上傳時間: 2018-01-18 11:39:26 (UTC+8)
    出版者: Taylor & Francis Inc
    摘要: Silver and gold electrodes were used with high-performance liquid chromatography and an electrochemical detector to determine nicotinic acid and its metabolites (1-methylnicotinamide chloride, nicotinic acid hydroxamate, nicotinamide, nicotinic acid, and methyl nicotinate). Nicotinic acid derivatives were more efficiently oxidized on a gold electrode than on a silver electrode. In direct current mode, with the current at a constant potential and with suitable experimental parameters, linear dynamic range for these derivatives was from 0.4 to 8.0 mg L-1. The limits of quantification were less than 1.0 ng. The developed method was used to determine nicotinic acid and its derivatives in human urine, cosmetics, and pharmaceuticals. The results for high-performance liquid chromatography with electrochemical and ultraviolet detection were comparable.
    關聯: Analytical Letters, v.49 n.10, pp.1467-1479
    Appears in Collections:[醫藥化學系 ] 期刊論文

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