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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30991


    標題: The Early Predictive Value of Right Ventricular Strain in Epirubicin-Induced Cardiotoxicity in Patients with Breast Cancer
    作者: Chang, Wei-Ting
    Shih, Jhih-Yuan
    Feng, Yin-Hsun
    Chiang, Chun-Yen
    Kuo, Yu Hsuan
    Chen, Wei-Yu
    Wu, Hong-Chang
    Cheng, Juei-Tang
    Wang, Jhi-Joung
    Chen, Zhih-Cherng
    貢獻者: Chi Mei Med Ctr, Div Cardiol, Dept Internal Med
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Chi Mei Med Ctr, Dept Internal Med, Div Oncol
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Pharm
    關鍵字: Dyspnea
    Epirubicin
    Right ventricle
    Speckle-tracking echocardiography
    dysfunction
    日期: 2016-09
    上傳時間: 2018-01-18 11:39:23 (UTC+8)
    出版者: Taiwan Soc Cardiology
    摘要: Background: As cancer therapies have improved, patient life spans have been extended but quality of life has been threatened by chemotherapy induced cardiotoxicity. Most cardiac complications remain unobserved until specific symptoms develop. Speckle-tracking echocardiography is a sensitive imaging modality in detecting early occult myocardial dysfunction. Methods: A total number of 35 patients newly diagnosed with breast cancer and preparing for epirubicin therapy were prospectively recruited. Echocardiography, including speckle-tracking echocardiography, was performed sequentially at baseline (T1), after the first cycle (T2) and after the third cycle (T3) of epirubicin. At each visit, the severity of dyspnea was evaluated by the assessment scale. Results: Compared with the baseline, right ventricular longitudinal strain (RVLS_FW) at T2 significantly declined (-22.49 +/- 4.97 vs. -18.48 +/- 4.46, p = 0.001), which was also positively associated with the development of dyspnea (R-2 = 0.8, p = 0.01). At T3, both the left ventricular global longitudinal strain and RVLS_FW were significantly impaired (-21.4 +/- 4.12 vs.-16.94 +/- 6.81%; -22.49 +/- 4.97 vs. -16.86 +/- 7.27%, p = 0.01; 0.001, respectively). Also, the accumulating dose of epirubicin positively correlated with the development of dyspnea (R-2 = 0.38, p = 0.04) and the decline of RVLS_FW (R-2 = 0.53, p = 0.02). Notably, compared with the other echocardiographic parameters only RVLS_FW at the early stage (T2) significantly correlated with the development of dyspnea (odds ratio: 1.84, 95% confidence interval: 1.22-2.78, p = 0.04). Conclusions: RVLS_FW sensitively predicts dyspnea development in breast cancer patients receiving epirubicin therapy. However, larger scale studies are required to validate its role in long-term patient survival.
    關聯: Acta Cardiologica Sinica, v.32 n.5, pp.550-559
    Appears in Collections:[藥學系(所)] 期刊論文

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