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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30958


    標題: Thermo- and pH-Induced Self-Assembly of P(AA-b-NIPAAm-b-AA) Triblock Copolymers Synthesized via RAFT Polymerization
    作者: Kuo, Chih-Yu
    Don, Trong-Ming
    Hsu, Shih-Chi
    Lee, Chia-Fen
    Chiu, Wen-Yen
    Huang, Chih-Yuan
    貢獻者: Natl Taiwan Univ, Inst Polymer Sci & Engn
    Tamkang Univ, Dept Chem & Mat Engn
    Natl Taiwan Univ, Dept Mat Sci & Engn
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
    Natl Taiwan Univ, Dept Chem Engn
    關鍵字: block copolymer
    core-shell particles
    nanogels
    reversible addition fragmentation chain transfer (RAFT)
    RAFT polymerization
    self-assembly
    stimuli-sensitive polymers
    nanocarriers
    日期: 2016-04
    上傳時間: 2018-01-18 11:38:43 (UTC+8)
    出版者: Wiley
    摘要: A series of environmentally sensitive ABA triblock copolymers with different block lengths were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization from acrylic acid (AA) and N-isopropylacrylamide (NIPAAm). The GPC and H-1 NMR analyses demonstrated the narrow molecular weight distribution and precise chemical structure of the prepared P(AA-b-NIPAAm-b-AA) triblock copolymers owing to the controlled/living characteristics of RAFT polymerization. The lower critical solution temperature (LCST) of the triblock copolymers could be tailored by adjusting the length of PAA block and controlled by the pH value. Under heating, the triblock copolymers underwent self-assemble in dilute aqueous solution and formed nanoparticles revealed via TEM images. Physically crosslinked nanogels induced by inter-/intra-hydrogen bonding or core-shell micelle particles thus could be obtained by changing environmental conditions. With a well-defined structure and stimuli-responsive properties, the P(AA-b-NIPAAm-b-AA) copolymer is expected to be employed as a nanocarrier for biomedical applications in controlled-drug delivery and targeting therapy. (C)2015 Wiley Periodicals, Inc.
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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