Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30952
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    標題: Therapeutic treatment with ascorbate rescues mice from heat stroke-induced death by attenuating systemic inflammatory response and hypothalamic neuronal damage
    作者: Chang, Chia-Yu
    Chen, Jen-Yin
    Chen, Sheng-Hsien
    Cheng, Tain-Junn
    Lin, Mao-Tsun
    Hu, Miao-Lin
    貢獻者: Chi Mei Med Ctr, Dept Neurol
    Natl Chung Hsing Univ, Dept Food Sci & Appl Biotechnol
    Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
    Chi Mei Med Ctr, Dept Anesthesiol
    Da An Women & Children Hosp
    Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
    Chi Mei Med Ctr, Dept Med Res
    關鍵字: Ascorbate
    Heat stroke
    Systemic inflammatory response
    induction
    日期: 2016-04
    上傳時間: 2018-01-18 11:38:36 (UTC+8)
    出版者: Elsevier Science Inc
    摘要: The impact of ascorbate on oxidative stress-related diseases is moderate because of its limited oral bioavailability and rapid clearance. However, recent evidence of the clinical benefit of parenteral vitamin C administration has emerged, especially in critical care. Heatstroke is defined as a form of excessive hyperthermia associated with a systemic inflammatory response that results in multiple organ dysfunctions in which central nervous system disorders such as delirium, convulsions, and coma are predominant. The thermoregulatory, immune, coagulation and tissue injury responses of heatstroke closely resemble those observed during sepsis and are likely mediated by similar cellular mechanisms. This study was performed by using the characteristic high lethality rate and sepsis-mimic systemic inflammatory response of a murine model of heat stroke to test our hypothesis that supra-physiological doses of ascorbate may have therapeutic use in critical care. We demonstrated that parenteral administration of ascorbate abrogated the lethality and thermoregulatory dysfunction in murine model of heat stroke by attenuating heat stroke-induced accelerated systemic inflammatory, coagulation responses and the resultant multiple organ injury, especially in hypothalamus. Overall, our findings support the hypothesis and notion that supra-physiological doses of ascorbate may have therapeutic use in critical care. (C) 2016 Published by Elsevier Inc.
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