Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30949
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 16937/19260 (88%)
造访人次 : 7622588      在线人数 : 98
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    標題: Activation of endothelial NO synthase by a xanthine derivative ameliorates hypoxia-induced apoptosis in endothelial progenitor cells
    作者: Wu, Jiunn-Ren
    Hsu, Jong-Hau
    Dai, Zen-Kong
    Wu, Bin-Nan
    Chen, Ing-Jun
    Liou, Shu-Fen
    Yeh, Jwu-Lai
    貢獻者: Kaohsiung Med Univ, Dept Pediat, Kaohsiung Med Univ Hosp
    Kaohsiung Med Univ, Dept Paediat, Fac Med, Coll Med
    Kaohsiung Med Univ, Grad Inst Med, Coll Med
    Kaohsiung Med Univ, Dept & Grad Inst Pharmacol, Fac Med, Coll Med
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources
    關鍵字: apoptosis
    endothelial nitric oxide synthase
    endothelial progenitor cells
    日期: 2016-06
    上傳時間: 2018-01-18 11:38:32 (UTC+8)
    出版者: Wiley
    摘要: Objectives Endothelial damage is strongly associated with cardiovascular diseases such as atherosclerosis, thrombosis and hypertension. Endothelial progenitor cells (EPCs) are primitive bone marrow (BM) cells that possess the capacity to mature into endothelial cells and play a role in neovascularization and vascular remodelling. This study aimed to investigate whether KMUP-1, a synthetic xanthine-based derivative, atorvastatin and simvastatin, can prevent endothelial dysfunction and apoptosis induced by hypoxia and to elucidate the underlying mechanisms. Methods Mononuclear cells were separated and were induced to differentiate into EPCs. KMUP-1, atorvastatin or simvastatin were administered prior to hypoxia. Key findings We found that EPCs exposed to hypoxia increased apoptosis as well as diminished proliferation. Pretreatment with KMUP-1, atorvastatin and simvastatin significantly prevented hypoxia-induced EPCs death and apoptosis, with associated increased of the Bcl-2/Bax ratio, and reduced caspase-3 and caspase-9 expression. We also assessed the nitrite production and Ser(1177)-phospho-eNOS expression and found that KMUP-1, atorvastatin and simvastatin not only increased the secretion of NO compared with the hypoxia group but also upregulated the eNOS activation. Conclusions KMUP-1 inhibited hypoxia-induced dysfunction and apoptosis in EPCs, which may be mediated through suppressing oxidative stress, upregulating eNOS and downregulating the caspase-3 signalling pathway.
    显示于类别:[藥學系(所)] 期刊論文


    档案 描述 大小格式浏览次数

    在CNU IR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈