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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30943


    標題: The Inhibitory Mechanisms Study of 5,6,4 '-Trihydroxy-7,3 '-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability
    作者: Wang, Shih-Hao
    Liang, Chia-Hua
    Liang, Fong-Pin
    Ding, Hsiou-Yu
    Lin, Shiuan-Pey
    Huang, Guan-Jhong
    Lin, Wen-Chuan
    Juang, Shin-Hun
    貢獻者: China Med Univ, Sch Pharm
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Tajen Univ, Dept Pharm
    Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
    China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc
    關鍵字: Anisomeles ovata
    5,6,4'-trihydroxy-7
    3-dimethoxyflavone
    anti-inflammatory
    anti-oxidant
    reactive oxygen species
    mapks
    日期: 2016-02
    上傳時間: 2018-01-18 11:38:24 (UTC+8)
    出版者: Mdpi Ag
    摘要: The whole plant of Anisomeles ovata has been widely used in Taiwan for treating inflammation-related skin and liver diseases, however, the detailed pharmacology mechanisms have yet to be elucidated. In the present study, one of the major components, 5,6,4-trihydroxy-7,3-dimethoxyflavone (5-TDMF), was purified from a methanol extract of Anisomeles ovata. A pharmacological study of this compound suggests that 5-TDMF possesses potent free radical scavenging activity both in vitro and ex vivo. Furthermore, 5-TDMF reduces nitric oxide and pro-inflammatory cytokine production in LPC-treated RAW 264.7 cells through the attenuation of nitric oxide synthase and cyclooxygenase-2. Additional experiments suggest that of 5-TDMF interferes with nuclear factor-B translocation and mitogen-activated protein kinase pathways. These results identify 5-TDMF as an anti-oxidant and anti-inflammatory compound, explain the pharmacologic function of Anisomeles ovata and suggest its great potential as a new anti-inflammatory remedy.
    關聯: Molecules, v.21 n.2, 136
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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