English  |  正體中文  |  简体中文  |  Items with full text/Total items : 16812/19099 (88%)
Visitors : 6832825      Online Users : 617
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30941


    標題: Prognostic Factors in Patients With Pulmonary Hypertension-A Nationwide Cohort Study
    作者: Chang, Wei-Ting
    Weng, Shih-Feng
    Hsu, Chih-Hsin
    Shih, Jhih-Yuan
    Wang, Jhi-Joung
    Wu, Chun-Ying
    Chen, Zhih-Cherng
    貢獻者: Chi Mei Med Ctr, Dept Cardiol
    Chi Mei Med Ctr, Dept Med Res
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat
    Cheng Kung Univ Hosp, Dept Internal Med
    Taichung Vet Gen Hosp, Div Gastroenterol
    Chia Nan Univ Pharm & Sci, Dept Pharm
    關鍵字: age
    mortality
    pulmonary hypertension
    sex
    disease
    日期: 2016-09
    上傳時間: 2018-01-18 11:38:22 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: Background-Pulmonary hypertension (PH) is a rare but fatal condition. Large-scale studies to examine the prognostic factors are lacking. In the present study, we aimed to investigate the factors associated with overall mortality in PH patients. Methods and Results-Based on Taiwan's National Health Insurance Database, we identified 1092 newly identified PH patients between 1999 and 2011. These patients were matched with 8736 healthy subjects based on propensity score calculated with age, sex, and chronic cardiovascular risk factors. Overall mortality, death incidence rate ratio, and hazard ratio were calculated. Patients with PH had a higher mortality than controls (56.45 versus 18.51 per 1000 person-years, P<0.0001), with hazard ratio at 3.3 (95% CI: 2.92-3.73, P<0.001). The long-term survival rates of the PH patients at 1, 5, and 10 years were 87.9%, 72.5%, and 62.6%, respectively, which were significantly lower than controls with 98.4%, 90.8%, and 83.6% at 1, 5, and 10 years, respectively. Among patients with PH, the mortality rate was higher in the older and male patients. However, after stratifying by age and sex, the younger (<50 years) and female patients had a higher risk. Regarding different etiologies of PH, chronic obstructive pulmonary disease and pulmonary embolism led to most cases of mortality (adjusted hazard ratio: 3.2, 95% CI: 2.76-3.71 and 4.64, 95% CI: 2.74-7.87, P<0.05). Conclusions-PH has high mortality, especially in females, and patients with younger age and with chronic diseases. Chronic obstructive pulmonary disease and pulmonary embolism contributed to an increased risk of mortality in PH patients.
    關聯: Journal of the American Heart Association, v.5 n.9, e003579
    Appears in Collections:[藥學系(所)] 期刊論文

    Files in This Item:

    File Description SizeFormat
    30941.pdf858KbAdobe PDF34View/Open
    index.html0KbHTML166View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback