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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30941

    標題: Prognostic Factors in Patients With Pulmonary Hypertension-A Nationwide Cohort Study
    作者: Chang, Wei-Ting
    Weng, Shih-Feng
    Hsu, Chih-Hsin
    Shih, Jhih-Yuan
    Wang, Jhi-Joung
    Wu, Chun-Ying
    Chen, Zhih-Cherng
    貢獻者: Chi Mei Med Ctr, Dept Cardiol
    Chi Mei Med Ctr, Dept Med Res
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat
    Cheng Kung Univ Hosp, Dept Internal Med
    Taichung Vet Gen Hosp, Div Gastroenterol
    Chia Nan Univ Pharm & Sci, Dept Pharm
    關鍵字: age
    pulmonary hypertension
    日期: 2016-09
    上傳時間: 2018-01-18 11:38:22 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: Background-Pulmonary hypertension (PH) is a rare but fatal condition. Large-scale studies to examine the prognostic factors are lacking. In the present study, we aimed to investigate the factors associated with overall mortality in PH patients. Methods and Results-Based on Taiwan's National Health Insurance Database, we identified 1092 newly identified PH patients between 1999 and 2011. These patients were matched with 8736 healthy subjects based on propensity score calculated with age, sex, and chronic cardiovascular risk factors. Overall mortality, death incidence rate ratio, and hazard ratio were calculated. Patients with PH had a higher mortality than controls (56.45 versus 18.51 per 1000 person-years, P<0.0001), with hazard ratio at 3.3 (95% CI: 2.92-3.73, P<0.001). The long-term survival rates of the PH patients at 1, 5, and 10 years were 87.9%, 72.5%, and 62.6%, respectively, which were significantly lower than controls with 98.4%, 90.8%, and 83.6% at 1, 5, and 10 years, respectively. Among patients with PH, the mortality rate was higher in the older and male patients. However, after stratifying by age and sex, the younger (<50 years) and female patients had a higher risk. Regarding different etiologies of PH, chronic obstructive pulmonary disease and pulmonary embolism led to most cases of mortality (adjusted hazard ratio: 3.2, 95% CI: 2.76-3.71 and 4.64, 95% CI: 2.74-7.87, P<0.05). Conclusions-PH has high mortality, especially in females, and patients with younger age and with chronic diseases. Chronic obstructive pulmonary disease and pulmonary embolism contributed to an increased risk of mortality in PH patients.
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