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| 標題: | Lactobacillus pentosus strain LPS16 produces lactic acid, inhibiting multidrug-resistant Helicobacter pylori |
| 作者: | Zheng, Po-Xing
Fang, Hsin-Yi
Yang, Hsiao-Bai
Tien, Nai-Yueh
Wang, Ming-Cheng
Wu, Jiunn-Jong |
| 貢獻者: | Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci
Chia Nan Univ Pharm & Sci, Coll Pharm & Sci, Dept Biotechnol
Ton Yen Gen Hosp, Dept Pathol
Natl Cheng Kung Univ, Coll Med, Clin Pharm & Pharmaceut Sci
Natl Cheng Kung Univ Hosp, Dept Internal Med
Natl Cheng Kung Univ, Coll Med, Dept Med Lab Sci & Biotechnol
Natl Cheng Kung Univ, Ctr Infect Dis & Signal Res |
| 關鍵字: | Acid
Bactericidal
Helicobacter
Lactobacillus
mice |
| 日期: | 2016-04 |
| 上傳時間: | 2018-01-18 11:38:18 (UTC+8) |
| 出版者: | Elsevier Taiwan |
| 摘要: | Background/Purpose: Helicobacter pylori is a human gastric pathogen. Antibiotic resistance of H. pylori has become a problem increasing the failure of H. pylori eradication. Therefore alternative approaches are required. The aim of this study was to evaluate the anti -H. pylori activity of Lactobacillus pentosus strain LPS16 and the mechanism of its killing effect. Methods: The anti -H. pylori activity of LPS16 was determined by the disc diffusion test and time killing assay. High-performance liquid chromatography analysis was used to analyze the secreted compounds of LPS16. Sixty H. pylori strains isolated from different gastric diseases, having different antibiotic susceptibility were collected to analyze the spectrum of anti -H. pylori activity of LPS16. Adhesion ability of LPS16 to gastric epithelial cell lines was assayed by flow cytometry. Results: The anti -H. pylori activity of LPS16 depended on the secreted component, and lactic acid mediated bactericidal activity against H. pylori. The bactericidal activity did not vary significantly among the strains isolated from different diseases having different antibiotic susceptibility. Moreover, LPS16 can adhere on gastric epithelial cell lines AKG and MKN45. Conclusion: L. pentosus strain LPS16 had the broad-spectrum anti -H. pylon activity, suggesting that it can be used to prevent H. pylon infection. Copyright (C) 2014, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. All rights reserved. |
| 關聯: | Journal of Microbiology Immunology and Infection, v.49 n.2, pp.168-174 |
| 顯示於類別: | [生物科技系(所)] 期刊論文
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