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    標題: Secondhand Smoke Exposure Enhances Cardiac Fibrosis Effects on the Aging Rat Hearts
    作者: Wu, Jia-Ping
    Chang-Lee, Shu Nu
    Day, Cecilia Hsuan
    Ho, Tsung-Jung
    Viswanadha, Vijaya Padma
    Chung, Li-Chin
    Hwang, Jin-Ming
    Jong, Gwo-Ping
    Kuo, Wei-Wen
    Huang, Chih-Yang
    貢獻者: China Med Univ, Grad Inst Basic Med Sci
    Asia Univ, Dept Healthcare Adm
    MeiHo Univ, Dept Nursing
    China Med Univ, Grad Inst Chinese Med
    China Med Univ, Chinese Med Dept, Beigang Hosp
    Bharathiar Univ, Dept Biotechnol, Coimbatore
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Chung Shan Med Univ, Sch Appl Chem
    Armed Force Taichung Gen Hosp, Div Cardiol
    China Med Univ, Dept Biol Sci & Technol
    Asia Univ, Dept Hlth & Nutr Biotechnol
    關鍵字: Aging
    Basic fibroblast growth factors
    Connective tissue growth factor
    Extracellular matrix
    Secondhand smoke exposure
    infarction
    日期: 2016-09
    上傳時間: 2018-01-18 11:38:15 (UTC+8)
    出版者: Taiwan Soc Cardiology
    摘要: Background: Examining aging rats exposed to secondhand smoke (SHS) engenders changes in left ventricular remodeling due to age- or disease-dependent alterations. Methods: Rats were placed in whole-body exposure chambers and exposed to 10 cigarettes. Filtered air was introduced into the chamber at a low rate. Rats were exposed to SHS for 30 min, twice a day, 5 days per week for 1 month. After 4 weeks SHS exposure, rats were sacrificed for morphological study with trichome staining and left ventricular remodeling related protein analysis using western blot. Results: Characteristic fibrotic morphology in the left ventricle increased significantly with aging and exposure to SHS. Exposure to SHS elevated TGF1 beta 1/p-Smad2/3/CTGF and MMP2/MMP9 protein expression levels (p < 0.05). No significant differences in FGF-2 and UPA protein expression were noted as a result of SHS exposure. However, TIMP-1, TIMP-2, TIMP-3 and TIMP-4 protein expression were suppressed by SHS exposure. We also observed increased TGF beta 1/p-Smad2/3/CTGF (p < 0.01), FGF-2/UPA (p < 0.05) and decreased TIMPs protein expression levels. Corresponding MMP2 and MMP9 upregulation occurred with aging and exposure to SHS. TGF beta 1/p-Smad2/3/CTGF and FGF-2/UPA protein expression from SHS exposure were higher than that from aging. In contrast, MMP2 and MMP9 were increased in aging rats compared with SHS exposed rats (p < 0.05); however, TIMP-1 (p < 0.01), TIMP-2 (p < 0.01) and TIMP-3 (p < 0.05) were decreased. TIMP-4 protein expression levels were decreased compared with SHS exposed rats (p < 0.01). Conclusions: Aging and SHS exposure in rats will produce elevated fibrosis. Exposure to SHS will accelerate aging and left ventricular fibrosis.
    關聯: Acta Cardiologica Sinica, v.32 n.5, pp.594-603
    Appears in Collections:[醫務管理系(所)] 期刊論文

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