Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30904
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    Title: Incidence and survival of retinoblastoma in Taiwan: a nationwide population-based study 1998-2011
    Authors: Li, Su-Yin
    Chen, Solomon Chih-Cheng
    Tsai, Ching-Fang
    Sheu, Shew-Meei
    Yeh, Jun-Jun
    Tsai, Chong-Bin
    Contributors: Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Family Med
    Chia Nan Univ Pharm & Sci
    Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Med Res
    Taipei Med Univ, Coll Med, Sch Med, Dept Pediat
    Meiho Univ
    Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Ophthalmol
    Keywords: intraarterial chemotherapy
    usa 1975-2004
    epidemiology
    program
    vision
    Date: 2016-06
    Issue Date: 2018-01-18 11:37:38 (UTC+8)
    Publisher: Bmj Publishing Group
    Abstract: Objective To study the epidemiology of retinoblastoma in Taiwan from 1998 to 2011. Design This was a retrospective population-based cohort study using the Taiwan National Health Insurance Research Database. Results The present study included 154 patients (92 males, 62 females) with retinoblastoma and the documented overall retinoblastoma incidence was 1 in 17 373 live births without a notable trend over the study period. The incidence per million live births examined by gender was 65.8 for males and 48.5 for females. The age-specific sex ratio increased from 1.4 at age younger than 1 year to 3.0 above age 4 years. Enucleation was performed in 109 (70.8%) children with retinoblastoma, and it was more prevalent in males than in females (77.2% vs 61.3%, p=0.0335). Multivariate Cox regression analyses with adjustment for diagnostic age, sex, and birth year elucidated that enucleation was a significant factor associated with survival (OR 0.27, 95% CI 0.10 to 0.61). Conclusions The incidence of retinoblastoma in Taiwan exhibited no marked trend over time. There were more cases of males than females and the male-to-female rate ratio increased with age. Survival outcome was significantly associated with the intervention of enucleation.
    Appears in Collections:[Dept. of Childhood Education and Nursery] Periodical Articles

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