本研究是將不同比例的阿斯匹靈Aspirin / 羧甲基纖維素CMC /聚麩胺酸PGA 溶液加入不同比例的氯化鈣溶液中，Ca2+離子分別與 CMC、PGA 上的羧基反應，形成交聯網狀結構。不同比例的高分子決定顆粒的物性，如粒徑大小、比表面積、藥物包埋率，並影響藥物的釋放的情況。 Nowadays the factory all over the world are face with the difficult to invent the new drug, except develop biopharmaceutical otherwise , make the old drug with new medicament to achieve the better curative. Human take medicine into body, after digestion the drug potency in blood have to maintain in effective concentration, if the drug concentration is too height, it will have secondary action. If the drug concentration is too low, it will do not have the drug effect. So that a good medicament have the advantage that release drug rate slowly and release drug with long time , use the minimum drug to achieve the best effect. This experiment is purpose to make medicament with carboxyl methyl cellulose and r-polymer glutamic acid.