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    Title: A.nidulans 之orsellinic acid/F9775 基因叢集二次代謝物及其衍生物之相關研究 ─ 子計畫二: A.nidulans之orsellinic acid/F9775基因叢集二次代謝物之衍生物合成研究
    Authors: 何文岳
    Contributors: 化妝品應用與管理系
    Date: 2010
    Issue Date: 2017-11-29 16:52:02 (UTC+8)
    Abstract: 由於真菌之二次代謝物具有結構多樣性與生物活性,因而成為新藥開發的重要研究方向之一。Gerfelin 為小巢狀麴菌(Aspergillus nidulans)之orsellinic acid/F9775 基因叢集二次代謝物,其具有抑制geranylgeranyl diphosphate (GGPP)合成酶的活性。本研究以3,4,5-trimethoxyphenol 與ethyl 4-bromobenzoate 為起始物,進行Pd 催化的Ullmann 反應以及水解反應,可獲得gerfelin 結構衍生物10 及11。在生物活性試驗中,化合物10 及11 對A549 (human lung adenocarcinoma epithelial cell line)的IC50 分別為2.1 μM 與12.3 μM,具有顯著之細胞毒活性之差異。
    Relation: 計畫編號:CN9910;計畫年度:99
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Chna Project

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