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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30279


    標題: 用於抑制皮膚黑色素生成之3-羥基-4-甲氧基苯甲酸
    3-Hydroxy-4-Methoxybenzoic Acid for Inhibiting Skin Melanin formation
    作者: 梁家華
    丁秀玉
    周宗翰
    貢獻者: 化粧品應用與管理系
    日期: 2015-04-01
    上傳時間: 2017-04-27 15:30:19 (UTC+8)
    摘要: 本發明係有關於一種用於抑制皮膚黑色素生成之3-羥基-4-甲氧基苯甲酸,其可抑制皮膚細胞黑色素分泌作用、抑制細胞內酪胺酸?與多巴氧化?活性之作用,並可調控黑色素生成相關之基因與蛋白質表現,包括黑素皮質素受體1、小眼相關轉錄因子、酪胺酸?、酪胺酸?相關蛋白2和酪胺酸?相關蛋白1,並具有清除DPPH和ABTS自由基能力;藉此,可作為皮膚黑色素抑制劑、美白淡斑或抗氧化之化妝材料組成物、食品添加物或醫藥組成物。
    The invention relates to a 3-hydroxy-4-methoxybenzoic acid (HMA) for inhibiting the skin melanin formation. It can be used to inhibit the secretion of melanin in skin cells, inhibit intracellular tyrosinase and DOPA oxidase activities, and regulate melanin-related genes and proteins expression comprising melanocortin 1 receptor (MC1R), microphthalmia associated transcription factor (MITF), tyrosinase, tyrosinase related protein-2 (TRP-2), and tyrosinase related protein-1 (TRP-1). Furthermore, it has the ability to scavenge DPPH and ABTS radicals. Therefore, the present invention can further be used as cosmetic compositions, food additives, and pharmaceutical compositions for purpose of inhibiting the skin melanin formation, whitening, and anti-oxidation.
    關聯: 專利編號:I562785、公開號:201511776
    申請號:102135128
    國際分類:A61K-008/368(2006.01);A61K-031/192(2006.01);A61P-017/00(2006.01);A61P-017/18(2006.01);A61Q-019/02(2006.01);A61Q-019/08(2006.01)
    專利公報:13卷7期、43卷36期
    Appears in Collections:[化妝品應用與管理系(所)] 專利

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