Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/29759
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18034/20233 (89%)
Visitors : 23351404      Online Users : 445
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/29759


    Title: Comparison of the impact of "fast decline" in residual renal function and "initial anuria" on long-term outcomes in capd patients
    Authors: Lu, Yi-Hua
    Hwang, Jyh-Chang
    Jiang, Ming-Yan
    Wang, Charn-Ting
    Contributors: 醫務管理系
    Keywords: CAPD
    anuria
    residual renal function
    diabetes mellitus
    survival
    co-morbidity
    Date: 2015-03
    Issue Date: 2016-04-19 19:07:10 (UTC+8)
    Publisher: Multimed Inc
    Abstract: Background: Residual renal function (RRF) is pivotal to long-term outcomes, while rapid RRF decline (RRFD) is associated with mortality risk for continuous ambulatory peritoneal dialysis (CAPD) patients. This study was conducted to compare the impact of "initial anuria" and rapid RRFD on the long-term prognosis of CAPD patients.
    Method: According to the timing of anuria and the slope of RRFD, a total of 255 incident CAPD patients were divided into 3 groups. For the "anuria" group, anuria was detected from CAPD initiation and persisted for > 6 months (n = 27). Based on the median of the RRFD slope, the other 228 non-anuric patients were divided into a "slow decliner" group (n= 114), and a "rapid decliner" group (n = 114). The maximal observation period was 120 months.
    Results: Logistic regression tests indicated that the "anuria" group was associated with previous hemodialysis > 3 months (odds ratio [OR]: 8.52, 95% confidence interval [CI]: 3.12 -23.28), and female (OR: 0.29, 95% CI: 0.09 0.90), while the "fast decliner" group with higher Davies co-morbidity scores (DCS) (OR: 1.52; 95% CI: 1.08 -2.14), body mass index (BMI) (OR: 1.12; 95% CI: 1.04 -1.21), and male (OR: 1.12; 95% CI: 1.04 -1.21). After adjusting for DCS, the "fast decliner"group (hazard ratio [HR]: 0.37; 95% CI: 0.17 -0.80) showed a better outcome than that of the "anuria" group (reference = 1). Both baseline RRF (beta = -0.24; p < 0.001) and DCS (beta = -3.76; p < 0.001) showed inverse linear correlations to the slope of RRFD. From the Cox proportional analyses, higher baseline RRF (HR: 0.92; 95% CI: 0.88 -0.97) and higher slope of RRFD (slower decline in RRF) (HR: 0.90; 95% CI: 0.85 -0.96) were independent factors for less mortality risk in patients with DCS = 0. However, only a higher slope of RRFD (HR: 0.97; 95% CI: 0.94 -0.99) was significant for better survival in CAPD patients with DCS > 0.
    Conclusion: Compared to the baseline RRF, CAPD patients with co-morbidities that rapidly deteriorate RRFD are more crucially associated with long-term mortality risk.
    Relation: Peritoneal Dialysis International, v.35 n.2, pp.172-179
    Appears in Collections:[Dept. of Hospital and Health (including master's program)] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML1337View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback