Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/29758
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/29758


    Title: Amisulpride and symptomatic bradycardia: a case report
    Authors: Huang, Li-Chung
    Huang, Li-Yen
    Tseng, Shih-Yen
    Hou, Yuh-Ming
    Hsiao, Cheng-Cheng
    Contributors: 醫務管理系
    Keywords: Badycardia
    Psychotic disorder
    Amisulpride
    Adverse drug reaction
    Date: 2015-09
    Issue Date: 2016-04-19 19:07:08 (UTC+8)
    Publisher: Elsevier Science Inc
    Abstract: Objective: Amisulpride is a second-generation antipsychotic agent indicated for the treatment of schizophrenia and other major psychotic illnesses. Amisulpride-induced bradycardia is a rare condition of unknown etiology and mechanism. Asymptomatic bradycardia has been associated with amisulpride in only two cases. In our case, the association was rated as "probable" on the Naranjo adverse drug reaction probability scale.Method: Case report.Results: A 45-year-old male patient developed symptomatic bradycardia during usage of amisulpride (400800 mg/day), which dramatically improved after the complete termination of amisulpride usage. The psychiatric condition remained relatively stable without bradycardia after administration of another antipsychotic agent [risperidone (3 mg/day)].Conclusion: This is the first case report of symptomatic bradycardia associated with the use of amisulpride. Although bradycardia is a rare adverse reaction to antipsychotics, this finding may alert psychiatrists and physicians to this antipsychotic drug side effect. Further study is needed to disclose the role of antipsychotics in bringing about symptomatic bradycardia. (C) 2015 Elsevier Inc. All rights reserved.
    Relation: General Hospital Psychiatry, v.37 n.5, Pages 497.e1–497.e2
    Appears in Collections:[Dept. of Hospital and Health (including master's program)] Periodical Articles

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