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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29732


    標題: Molecular Epidemiology of HIV-1 Infection among Men who Have Sex with Men in Taiwan in 2012
    作者: Huang, Szu-Wei
    Wang, Sheng-Fan
    Cowo, Angel E.
    Chen, Marcelo
    Lin, Yu-Ting
    Hung, Chun-Po
    Chen, Yi-Hsien
    Yang, Jyh-Yuan
    Tang, Hung-Jen
    Chen, Yi-Ming Arthur
    貢獻者: 保健營養系
    關鍵字: Sexually-transmitted-diseases
    Unprotected anal intercourse
    Injection-drug users
    Bisexual men
    Substance use
    Risk-factors
    San-francisco
    Young gay
    Subtype-b
    China
    日期: 2015-06
    上傳時間: 2016-04-19 19:06:13 (UTC+8)
    出版者: Public Library Science
    摘要: The number of men who have sex with men (MSM) infected with HIV-1 in Taiwan has increased rapidly in the past few years. The goal of this study was to conduct a molecular epidemiological study of HIV-1 infection among MSM in Taiwan to identify risk factors for intervention. Voluntary counseling program and anonymous testing were provided to patrons at 1 gay bar, 7 night clubs and 3 gay saunas in Taipei and New Taipei Cities in 2012. HIV-1 subtypes were determined using gag subtype-specific PCR and phylogenetic analysis by env sequences. Recent HIV-1 infection was determined using LAg-Avidity EIA. In-depth interviews and questionnaires were used to identify risk factors. The prevalence and incidence of HIV-1 among MSM in Taiwan were 4.38%(53/1,208) and 3.29 per 100 person-years, respectively. Of 49 cases genotyped, 48 (97.9%) were infected with subtype B and 1 with CRF01_AE (2%). Phylogenetic analysis of 46 HIV-1 strains showed that 25 (54.4%) subtype B strains formed 9 clusters with each other or with other local strains. The CRF01_ AE case clustered with a reference strain from a Thai blood donor with bootstrap value of 99. Multivariate logistic regression analysis showed that risk factors associated with HIV-1 infection included use of oil-based solution as lubricant (vs. saliva or waterbased lubricants, OR=4.23; p < 0.001); exclusively receptive role (vs. insertive role, OR=9.69; p < 0.001); versatile role (vs. insertive role, OR=6.45; p=0.003); oral sex (vs. insertive role, OR=11.93; p=0.044); times of sexual contact per week (2-3 vs. zero per week, OR=3.41; p=0.021); illegal drug use (OR=4.12; p < 0.001); and history of sexually transmitted diseases (OR=3.65; p=0.002). In conclusion, there was no new HIV-1 subtype or circulating recombinant in Taiwan in 2012. Misuse of oil-based solution as lubricant is a new risk factor identified among MSM in Taiwan. The Taiwan's Centers for Disease Control has created a video (www.youtube. com/watch?v= BinExvvOTMM&feature = iv& src_vid=BW81-PfmY3E&annotation_ id = annotation_2436493705) to correct such misconception in its AIDS prevention campaign.
    Appears in Collections:[保健營養系(所) ] 期刊論文

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